PDB entry 5kad

View 5kad on RCSB PDB site
Description: Protein Tyrosine Phosphatase 1B N193A mutant in complex with TCS401, closed state
Class: hydrolase/hydrolase inhibitor
Keywords: Protein tyrosine phosphatase, hydrolase-hydrolase inhibitor complex
Deposited on 2016-06-01, released 2017-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-01, with a file datestamp of 2017-02-24.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (5-End)
      • expression tag (1-4)
      • engineered mutation (197)
    Domains in SCOPe 2.08: d5kada1, d5kada2
  • Chain 'B':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (5-End)
      • expression tag (2-4)
      • engineered mutation (197)
    Domains in SCOPe 2.08: d5kadb1, d5kadb2
  • Heterogens: OTA, CL, TRS, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5kadA (A:)
    ghmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
    riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
    kgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfh
    yttwpdfgvpespasflaflfkvresgslspehgpvvvhcsagigrsgtfcladtclllm
    dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkels
    hedlep
    

    Sequence, based on observed residues (ATOM records): (download)
    >5kadA (A:)
    hmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsr
    iklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmek
    gslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhy
    ttwpdfgvpespasflaflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmd
    krkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfi
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5kadB (B:)
    ghmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
    riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
    kgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfh
    yttwpdfgvpespasflaflfkvresgslspehgpvvvhcsagigrsgtfcladtclllm
    dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkels
    hedlep
    

    Sequence, based on observed residues (ATOM records): (download)
    >5kadB (B:)
    masmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsri
    klhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekg
    slkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyt
    twpdfgvpespasflaflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdk
    rksvdikkvllemrkfrmgliqtadqlrfsylaviegakfim