PDB entry 5kab

View 5kab on RCSB PDB site
Description: Protein Tyrosine Phosphatase 1B Delta helix 7, P185G mutant in complex with TCS401, open state
Class: hydrolase
Keywords: Protein tyrosine phosphatase, HYDROLASE
Deposited on 2016-06-01, released 2017-03-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031 (5-End)
      • engineered mutation (189)
    Domains in SCOPe 2.08: d5kaba_
  • Heterogens: CL, OTA, TRS, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kabA (A:)
ghmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
kgslkcaqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfh
yttwpdfgvgespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllm
dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgd

    Sequence, based on observed residues (ATOM records): (download) 
    >5kabA (A:)
memekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklh
qedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslk
caqywpqkeekemifedtnlkltlisediksyytvrqlelenlttqetreilhfhyttwp
dfgvgespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkd
pssvdikkvllemrkfrmgliqtadqlrfsylaviegakfim