PDB entry 5ka3

View 5ka3 on RCSB PDB site
Description: Protein Tyrosine Phosphatase 1B YAYA (Y152A, Y153A) mutant in complex with TCS401, closed state
Class: hydrolase
Keywords: Protein tyrosine phosphatase, HYDROLASE
Deposited on 2016-06-01, released 2017-03-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-03-08, with a file datestamp of 2017-03-03.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: tyrosine-protein phosphatase non-receptor type 1
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN1, PTP1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P18031
      • engineered mutation (156-157)
    Domains in SCOPe 2.07: d5ka3a_
  • Heterogens: OTA, TRS, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5ka3A (A:)
    ghmasmemekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhs
    riklhqedndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvme
    kgslkcaqywpqkeekemifedtnlkltlisediksaatvrqlelenlttqetreilhfh
    yttwpdfgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllm
    dkrkdpssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkels
    hedlep
    

    Sequence, based on observed residues (ATOM records): (download)
    >5ka3A (A:)
    emekefeqidksgswaaiyqdirheasdfpcrvaklpknknrnryrdvspfdhsriklhq
    edndyinaslikmeeaqrsyiltqgplpntcghfwemvweqksrgvvmlnrvmekgslkc
    aqywpqkeekemifedtnlkltlisediksaatvrqlelenlttqetreilhfhyttwpd
    fgvpespasflnflfkvresgslspehgpvvvhcsagigrsgtfcladtclllmdkrkdp
    ssvdikkvllemrkfrmgliqtadqlrfsylaviegakfimgdssvqdqwkelsh