PDB entry 5k0c
View 5k0c on RCSB PDB site
Description: Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(2-phenylpropan-2-yl)-1H-pyrazol-5-yl]-1,3-thiazole
Class: transferase
Keywords: METHYLTRANSFERASE, NEUROTRANSMITTER DEGRADATION, CATECHOL, transferase
Deposited on
2016-05-17, released
2016-09-07
The last revision prior to the SCOPe 2.06 freeze date was dated
2016-09-07, with a file datestamp of
2016-09-02.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-214)
- engineered mutation (89)
- engineered mutation (93)
- engineered mutation (154)
Domains in SCOPe 2.06: d5k0ca_ - Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-214)
- engineered mutation (89)
- engineered mutation (93)
- engineered mutation (154)
Domains in SCOPe 2.06: d5k0cb_ - Heterogens: NHE, EDO, 6OZ, NA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>5k0cA (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgps
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>5k0cB (B:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgps