SCOPe 2.08: Structural Classification of Proteins

PDB entry 5k0b

View 5k0b on RCSB PDB site
Description: Crystal Structure of COMT in complex with 2,4-dimethyl-5-[3-(1-phenylethyl)-1H-pyrazol-5-yl]-1,3-thiazole
Class: transferase
Keywords: METHYLTRANSFERASE, NEUROTRANSMITTER DEGRADATION, CATECHOL, transferase
Deposited on 2016-05-17, released 2016-09-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-06-12, with a file datestamp of 2019-06-07.
Experiment type: XRAY
Resolution: 2.36 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0ba_
Chain 'B':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (0-End)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0bb_
Chain 'C':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (Start-216)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0bc_
Chain 'D':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (Start-216)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
  - expression tag (217)
Domains in SCOPe 2.08: d5k0bd1, d5k0bd2
Chain 'E':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (Start-216)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0be_
Chain 'F':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0bf_
Chain 'G':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0bg_
Chain 'H':
Compound: Catechol O-methyltransferase
Species: Rattus norvegicus [TaxId:10116]
Gene: COMT
Database cross-references and differences (RAF-indexed):
- Uniprot P22734 (Start-216)
  - engineered mutation (89)
  - engineered mutation (93)
  - engineered mutation (154)
Domains in SCOPe 2.08: d5k0bh_
Heterogens: 6PS, PO4, K, CL, CXS, EDO, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>5k0bA (A:)
gdtkeqrilryvqqnakpgdpqsvleaidtyctqkewamnvgdakgqimdavireyspsl
vlelgaycgysavrmarllqpgarlltmeinpdcaaitqqmlnfaglqdkvtilngasqd
lipqlkkkydvdtldmvfldhwkdrylpdtllleecgllrkgtvlladnvivpgtpdfla
yvrgsssfecthyssyleymkvvdglekaiyqgpssps