PDB entry 5jq6

View 5jq6 on RCSB PDB site
Description: Crystal structure of ClfA in complex with the Fab fragment of Tefibazumab
Class: immune system
Keywords: Staphylococcal infections, Clumping factor A, Fibrinogen, Tefibazumab, Aurexis, MSCRAMM, IMMUNE SYSTEM
Deposited on 2016-05-04, released 2017-01-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: clumping factor a
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: clfA
    Database cross-references and differences (RAF-indexed):
    • Uniprot G0XY13 (12-End)
      • expression tag (2-11)
      • engineered mutation (110)
      • engineered mutation (324)
  • Chain 'H':
    Compound: Tefibazumab FAB FRAGMENT HEAVY CHAIN
    Species: MUS MUSCULUS, HOMO SAPIENS [TaxId:10090, 9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JQ6 (0-End)
    Domains in SCOPe 2.08: d5jq6h_
  • Chain 'L':
    Compound: Tefibazumab FAB FRAGMENT LIGHT CHAIN
    Species: MUS MUSCULUS, HOMO SAPIENS [TaxId:10090, 9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5JQ6 (0-215)
    Domains in SCOPe 2.08: d5jq6l1, d5jq6l2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5jq6H (H:)
qvqlkesgpglvkpsqtlsitctisgfslsrysvhwvrqppgkglewlgmiwgggntdyn
salksrlsiskdnsknqvflkmnsltaadtavyycarkgefyygydgfvywgqgtlvtvs
sastkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssslgtqtyicnvnhkpsntkvdkraepk

    Sequence, based on observed residues (ATOM records): (download) 
    >5jq6H (H:)
qvqlkesgpglvkpsqtlsitctisgfslsrysvhwvrqppgkglewlgmiwgggntdyn
salksrlsiskdnsknqvflkmnsltaadtavyycarkgefyygydgfvywgqgtlvtvs
sastkgpsvfplapalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv
tvpssyicnvnhkpsntkvdkrae

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >5jq6L (L:)
divmtqspdslavslgervtmnckssqsvlyssnqknylawyqqkpgqspklliywastr
esgvpdrfsgsgsgtdftltissvqaedlavyychqylssytfgggtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstysl
sstltlskadyekhkvyacevthqglsspvtksanr

    Sequence, based on observed residues (ATOM records): (download) 
    >5jq6L (L:)
divmtqspdslavslgervtmnckssqsvlyssnqknylawyqqkpgqspklliywastr
esgvpdrfsgsgsgtdftltissvqaedlavyychqylssytfgggtkleikrtvaapsv
fifppsdeqlksgtasvvcllnnfypreakvqwkvnalqsgnsqesvteqdskdstysls
stltlskadyekhkvyacevthqgpvtksanr