PDB entry 5jhh

View 5jhh on RCSB PDB site
Description: Crystal structure of the ternary complex between the human RhoA, its inhibitor and the DH/PH domain of human ARHGEF11
Class: signaling protein/transcription/inhibitor
Keywords: RhoA-inhibitor-ARHGEF11 ternary complex, target-based pharmaceutical design, SIGNALING PROTEIN-TRANSCRIPTION-INHIBITOR complex
Deposited on 2016-04-21, released 2017-04-26
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-04-26, with a file datestamp of 2017-04-21.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5jhha1, d5jhha2
  • Chain 'B':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5jhhb_
  • Chain 'E':
    Compound: Rho guanine nucleotide exchange factor 11
    Species: Homo sapiens [TaxId:9606]
    Gene: ARHGEF11, KIAA0380
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5jhhe1, d5jhhe2
  • Chain 'F':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5jhhf_
  • Heterogens: GOL, RA0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5jhhA (A:)
mqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpr
eelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqf
csyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesi
ikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpl
aaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchskta
vgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwme
lleeavrna

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhhA (A:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchtfspv
lklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5jhhB (B:)
maairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdt
agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
a

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhhB (B:)
airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5jhhE (E:)
mqnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpr
eelarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqf
csyqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesi
ikhteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpl
aaefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchskta
vgssdskqtfspvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwme
lleeavrna

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhhE (E:)
qnwqhtvgkdvvagltqreidrqevinelfvteashlrtlrvldlifyqrmkkenlmpre
elarlfpnlpelieihnswceamkklreegpiikeisdlmlarfdgpareelqqvaaqfc
syqsialeliktkqrkesrfqlfmqeaeshpqcrrlqlrdliisemqrltkyplllesii
khteggtseheklcrardqcreilkyvneavkqtenrhrlegyqkrldatalerasnpla
aefksldlttrkmihegpltwriskdktldlhvllledllvllqkqdeklllkchsktfs
pvlklnavlirsvatdkraffiictsklgppqiyelvaltssdkntwmelleeavrna

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5jhhF (F:)
maairkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdt
agqedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
lrndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq
a

    Sequence, based on observed residues (ATOM records): (download) 
    >5jhhF (F:)
airkklvivgdgacgktcllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedydrlrplsypdtdvilmcfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlr
ndehtrrelakmkqepvkpeegrdmanrigafgymecsaktkdgvrevfematraalq