PDB entry 5j6s

View 5j6s on RCSB PDB site
Description: Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
Class: hydrolase
Keywords: Endoplasmic reticulum, aminopeptidase, hydrolase, Zn binding metallopeptidase
Deposited on 2016-04-05, released 2017-03-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-04-05, with a file datestamp of 2017-03-31.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • variant (391)
      • expression tag (960-961)
    Domains in SCOPe 2.07: d5j6sa1, d5j6sa2, d5j6sa3, d5j6sa4, d5j6sa5
  • Chain 'B':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • variant (391)
      • expression tag (960-962)
    Domains in SCOPe 2.07: d5j6sb1, d5j6sb2, d5j6sb3, d5j6sb4, d5j6sb5
  • Heterogens: ZN, NAG, BMA, 6GA, MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5j6sA (A:)
mfhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5j6sA (A:)
fpvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhs
kdleitnatlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqakl
gdgfegfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhia
lsnmpkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdk
rnqthyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfd
pktssasdklwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelq
fddyflnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgee
kfqkgiiqylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgena
evkemmttwtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhiplty
stsssnvihrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnht
llrpkdrvglihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdr
rnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaae
lfsqwmessgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstsk
hqekllklielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsy
dirmiisgttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptl
rtwlmvntrh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5j6sB (B:)
mfhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
klwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqfddyflnv
cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
rhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5j6sB (B:)
pvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhsk
dleitnatlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklg
dgfegfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhial
snmpkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkr
nqthyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdp
ktssasdklwvtrviahelahqwfgnlvtmewwndiwlnegfakymeliavnatypelqf
ddyflnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeek
fqkgiiqylkkfsyrnaknddlwsslsnsevkemmttwtlqkgipllvvkqdgcslrlqq
erflqgvfqedpewralqerylwhipltystsssnvihrhilksktdtldlpektswvkf
nvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldm
tyylqhetsspalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkg
svwdrmlrsallklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqtta
gwnylleqyelsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallhaia
rrpkgqqlawdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffeslea
qgshldifqtvletitknikwleknlptlrtwlmvntrhh