PDB entry 5hyi

View 5hyi on RCSB PDB site
Description: Glycosylated, disulfide-linked Hole-Hole Fc fragment
Class: immune system
Keywords: Bispecific antibody Fc engineering Knob-into-Hole, immune system
Deposited on 2016-02-01, released 2017-02-01
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-02-01, with a file datestamp of 2017-01-26.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.06: d5hyia1, d5hyia2
  • Chain 'B':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.06: d5hyib1, d5hyib2
  • Chain 'C':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.06: d5hyic1, d5hyic2
  • Chain 'D':
    Compound: Ig gamma-1 chain C region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHG1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01857
      • engineered mutation (128)
      • engineered mutation (145)
      • engineered mutation (147)
      • engineered mutation (186)
    Domains in SCOPe 2.06: d5hyid1, d5hyid2
  • Heterogens: NAG, BMA, MAN, GAL, FUC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hyiA (A:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hyiA (A:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrd
eltknqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksr
wqqgnvfscsvmhealhnhytqkslslsp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hyiB (B:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hyiB (B:)
ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsr
deltknqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdks
rwqqgnvfscsvmhealhnhytqkslsls

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hyiC (C:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hyiC (C:)
gpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeqy
nstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsrd
eltknqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdksr
wqqgnvfscsvmhealhnhytqkslsls

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5hyiD (D:)
dkthtcppcpapellggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvd
gvevhnaktkpreeqynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskak
gqprepqvctlppsrdeltknqvslscavkgfypsdiavewesngqpennykttppvlds
dgsfflvskltvdksrwqqgnvfscsvmhealhnhytqkslslspgk

    Sequence, based on observed residues (ATOM records): (download) 
    >5hyiD (D:)
ggpsvflfppkpkdtlmisrtpevtcvvvdvshedpevkfnwyvdgvevhnaktkpreeq
ynstyrvvsvltvlhqdwlngkeykckvsnkalpapiektiskakgqprepqvctlppsr
deltknqvslscavkgfypsdiavewesngqpennykttppvldsdgsfflvskltvdks
rwqqgnvfscsvmhealhnhytqkslsls