PDB entry 5hrp
View 5hrp on RCSB PDB site
Description: HIV Integrase Catalytic Domain containing F185K + A124T mutations complexed with GSK0002
Class: transferase/inhibitor
Keywords: Viral DNA integration, DNA Binding, LEDGF Binding, VIRAL PROTEIN, TRANSFERASE-INHIBITOR complex
Deposited on
2016-01-24, released
2016-12-14
The last revision prior to the SCOPe 2.08 freeze date was dated
2016-12-21, with a file datestamp of
2016-12-16.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: N/A
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: integrase
Species: Human immunodeficiency virus 1 [TaxId:11706]
Gene: gag-pol
Database cross-references and differences (RAF-indexed):
- Uniprot P04585
- conflict (74)
- engineered mutation (75)
- conflict (78)
- engineered mutation (136)
Domains in SCOPe 2.08: d5hrpa_ - Heterogens: CAC, SO4, EDO, 65P, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5hrpA (A:)
gmhgqvdcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrw
pvktihtdngsnftsttvkaacwwagikqefgipynpqsqgvvesmnkelkkiigqvrdq
aehlktavqmavfihnkkrkggiggysagerivdiiatdiqtke
Sequence, based on observed residues (ATOM records): (download)
>5hrpA (A:)
cspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktiht
dngsnftsttvkaacwwagikqgvvesmnkelkkiigqvrdqaehlktavqmavfihnkk
rkgysagerivdiiatdiq