PDB entry 5hfr

View 5hfr on RCSB PDB site
Description: Crystal structure of the second bromodomain H395R mutant of human BRD3
Class: transcription
Keywords: Transcription regulation, post translational modifications recognition, transcription
Deposited on 2016-01-07, released 2016-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-01-20, with a file datestamp of 2016-01-15.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (Start-112)
      • engineered mutation (91)
    Domains in SCOPe 2.08: d5hfra_
  • Chain 'B':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (Start-112)
      • engineered mutation (91)
    Domains in SCOPe 2.08: d5hfrb_
  • Chain 'C':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (Start-112)
      • engineered mutation (91)
    Domains in SCOPe 2.08: d5hfrc_
  • Chain 'D':
    Compound: Bromodomain-containing protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD3, KIAA0043, RING3L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15059 (Start-112)
      • engineered mutation (91)
    Domains in SCOPe 2.08: d5hfrd_
  • Heterogens: NO3, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5hfrA (A:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >5hfrA (A:)
klsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmd
greypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hfrB (B:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >5hfrB (B:)
klsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmd
greypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5hfrC (C:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >5hfrC (C:)
lsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmdg
reypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5hfrD (D:)
smgklsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkr
kmdgreypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp

    Sequence, based on observed residues (ATOM records): (download) 
    >5hfrD (D:)
lsehlrycdsilremlskkhaayawpfykpvdaealelhdyhdiikhpmdlstvkrkmdg
reypdaqgfaadvrlmfsncykynppdrevvamarklqdvfemrfakmp