PDB entry 5he3

View 5he3 on RCSB PDB site
Description: Bovine GRK2 in complex with Gbetagamma subunits and CCG224411
Class: transferase/transferase inhibitor
Keywords: RGS, kinase, PH, WD-40, inhibitor complex, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2016-01-05, released 2016-05-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 2.74 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-adrenergic receptor kinase 1
    Species: Bos taurus [TaxId:9913]
    Gene: ADRBK1, GRK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5he3a1, d5he3a2, d5he3a3
  • Chain 'B':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GNB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5he3b_
  • Chain 'G':
    Compound: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
    Species: Homo sapiens [TaxId:9606]
    Gene: GNG2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5he3g_
  • Heterogens: MG, FF1, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5he3A (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefyeei
    kkyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
    spffrsldwqmvflqkyppplipprgevnaadafdigsfdeedtkgiklldsdqelyrnf
    pltiserwqqevaetvfdtinaetdrlearkktknkqlgheedyalgkdcimhgymskmg
    npfltqwqrryfylfpnrlewrgegeapqslltmeeiqsveetqikerkclllkirggkq
    fvlqcdsdpelvqwkkelrdayreaqqlvqrvpkmknkprs
    

    Sequence, based on observed residues (ATOM records): (download)
    >5he3A (A:)
    kkillpepsirsvmqkyledrgevtfekifsqklgyllfrdfclkhleeakplvefyeei
    kkyekleteeerlvcsreifdtyimkellacshpfsksaiehvqghlvkkqvppdlfqpy
    ieeicqnlrgdvfqkfiesdkftrfcqwknvelnihltmndfsvhriigrggfgevygcr
    kadtgkmyamkcldkkrikmkqgetlalnerimlslvstgdcpfivcmsyafhtpdklsf
    ildlmnggdlhyhlsqhgvfseadmrfyaaeiilglehmhnrfvvyrdlkpanilldehg
    hvrisdlglacdfskkkphasvgthgymapevlqkgvaydssadwfslgcmlfkllrghs
    pfrqhktkdkheidrmtltmavelpdsfspelrsllegllqrdvnrrlgclgrgaqevke
    spffrsldwqmvflqkyppplipprtkgiklldsdqelyrnfpltiserwqqevaetvfd
    tinaetdrlearkktknkqlgheedyalgkdcimhgymskmgnpfltqwqrryfylfpnr
    lewrgegeapqslltmeeiqsveetqikerkclllkirggkqfvlqcdsdpelvqwkkel
    rdayreaqqlvqrvpkmknkprs
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >5he3B (B:)
    seldqlrqeaeqlknqirdarkacadatlsqitnnidpvgriqmrtrrtlrghlakiyam
    hwgtdsrllvsasqdgkliiwdsyttnkvhaiplrsswvmtcayapsgnyvacggldnic
    siynlktregnvrvsrelaghtgylsccrflddnqivtssgdttcalwdietgqqtttft
    ghtgdvmslslapdtrlfvsgacdasaklwdvregmcrqtftghesdinaicffpngnaf
    atgsddatcrlfdlradqelmtyshdniicgitsvsfsksgrlllagyddfncnvwdalk
    adragvlaghdnrvsclgvtddgmavatgswdsflkiwn
    

  • Chain 'G':
    Sequence, based on SEQRES records: (download)
    >5he3G (G:)
    masnntasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenp
    frekkffcail
    

    Sequence, based on observed residues (ATOM records): (download)
    >5he3G (G:)
    tasiaqarklveqlkmeanidrikvskaaadlmayceahakedplltpvpasenpfre