PDB entry 5h2u

View 5h2u on RCSB PDB site
Description: Crystal structure of PTK6 Kinase Domain complexed with Dasatinib
Class: transferase
Keywords: Transferase, Kinase, BRK, PTK6, Dasatinib
Deposited on 2016-10-18, released 2017-01-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-01-25, with a file datestamp of 2017-01-20.
Experiment type: XRAY
Resolution: 2.24 Å
R-factor: N/A
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Protein-tyrosine kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13882 (1-262)
      • expression tag (0)
      • engineered mutation (249)
      • expression tag (263-266)
    Domains in SCOPe 2.08: d5h2ua1, d5h2ua2, d5h2ua3
  • Chain 'B':
    Compound: Protein-tyrosine kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13882 (1-262)
      • expression tag (0)
      • engineered mutation (249)
      • expression tag (263-264)
    Domains in SCOPe 2.08: d5h2ub1, d5h2ub2, d5h2ub3
  • Chain 'C':
    Compound: Protein-tyrosine kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13882 (1-262)
      • expression tag (0)
      • engineered mutation (249)
      • expression tag (263-265)
    Domains in SCOPe 2.08: d5h2uc1, d5h2uc2, d5h2uc3
  • Chain 'D':
    Compound: Protein-tyrosine kinase 6
    Species: Homo sapiens [TaxId:9606]
    Gene: PTK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13882 (1-262)
      • expression tag (0)
      • engineered mutation (249)
      • expression tag (263-264)
    Domains in SCOPe 2.08: d5h2ud1, d5h2ud2, d5h2ud3
  • Heterogens: 1N1, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5h2uA (A:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaegmcyl
    esqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrgh
    ystksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltc
    wcrdpeqrptfkalrerlssftshhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5h2uA (A:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrsdekvlpvselldiawqvaegmcyle
    sqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrghy
    stksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltcw
    crdpeqrptfkalrerlssftshhhh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5h2uB (B:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaegmcyl
    esqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrgh
    ystksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltc
    wcrdpeqrptfkalrerlssftshhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5h2uB (B:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrsdekvlpvselldiawqvaegmcyle
    sqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrghy
    stksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltcw
    crdpeqrptfkalrerlssftshh
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >5h2uC (C:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaegmcyl
    esqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrgh
    ystksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltc
    wcrdpeqrptfkalrerlssftshhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5h2uC (C:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrsdekvlpvselldiawqvaegmcyle
    sqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrghy
    stksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltcw
    crdpeqrptfkalrerlssftshhh
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >5h2uD (D:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrdsdekvlpvselldiawqvaegmcyl
    esqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrgh
    ystksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltc
    wcrdpeqrptfkalrerlssftshhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5h2uD (D:)
    merpreeftlcrklgsgyfgevfeglwkdrvqvaikvisrdnllhqqmlqseiqamkklr
    hkhilalyavvsvgdpvyiitelmakgsllellrsdekvlpvselldiawqvaegmcyle
    sqnyihrdlaarnilvgentlckvgdfglarlikedvylshdhnipykwtapealsrghy
    stksdvwsfgillhemfsrgqvpypgmsnheaflrvdagyrmpcplecppsvhklmltcw
    crdpeqrptfkalrerlssftshh