PDB entry 5grm

View 5grm on RCSB PDB site
Description: Crystal structure of rat STING in complex with cyclic GMP-AMP with 2'5'and 3'5'phosphodiester linkage(2'3'-cGAMP)
Class: immune system
Keywords: Rat STING, 2'3'-cGAMP, IMMUNE SYSTEM
Deposited on 2016-08-11, released 2017-10-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.55 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Stimulator of interferon genes protein
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Tmem173, Sting
    Database cross-references and differences (RAF-indexed):
    • Uniprot F1M391 (23-End)
      • expression tag (16-22)
    Domains in SCOPe 2.08: d5grma1, d5grma2
  • Chain 'B':
    Compound: Stimulator of interferon genes protein
    Species: Rattus norvegicus [TaxId:10116]
    Gene: Tmem173, Sting
    Database cross-references and differences (RAF-indexed):
    • Uniprot F1M391 (23-209)
      • expression tag (20-22)
    Domains in SCOPe 2.08: d5grmb1, d5grmb2
  • Heterogens: 1SY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5grmA (A:)
    mgsshhhhhhssgenlyfqgshmvahglawsyyigylklilpglqarirmfnqlhnnmls
    gagsrrlyilfpldcgvpddlsvadpnirfrdmlpqqntdragvknraysnsvyelleng
    qpagacileyatplqtlfamsqdgkagfsredrleqaklfcrtleeiladvpesrnhcrl
    ivyqeseegnsfslsqevlrhirqeekeev
    

    Sequence, based on observed residues (ATOM records): (download)
    >5grmA (A:)
    yfqgshmvahglawsyyigylklilpglqarirmfnqlhnnmlsgagsrrlyilfpldcg
    vpddlsvadpnirfrdmlpqqntdragvknraysnsvyellengqpagacileyatplqt
    lfamsqdgkagfsredrleqaklfcrtleeiladvpesrnhcrlivyqeseegnsfslsq
    evlrhirq
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5grmB (B:)
    mgsshhhhhhssgenlyfqgshmvahglawsyyigylklilpglqarirmfnqlhnnmls
    gagsrrlyilfpldcgvpddlsvadpnirfrdmlpqqntdragvknraysnsvyelleng
    qpagacileyatplqtlfamsqdgkagfsredrleqaklfcrtleeiladvpesrnhcrl
    ivyqeseegnsfslsqevlrhirqeekeev
    

    Sequence, based on observed residues (ATOM records): (download)
    >5grmB (B:)
    shmvahglawsyyigylklilpglqarirmfnqlhnnmlsgagsrrlyilfpldcgvpdd
    lsvadpnirfrdmlpqqntdragvknraysnsvyellengqpagacileyatplqtlfam
    sqdgkagfsredrleqaklfcrtleeiladvpesrnhcrlivyqeseegnsfslsqevlr
    hirqeekeev