PDB entry 5g01

View 5g01 on RCSB PDB site
Description: An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C
Class: lyase
Keywords: lyase, natural product inhibitor, engineered proteins, carbonic anhydrase
Deposited on 2016-03-16, released 2016-05-25
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-05-25, with a file datestamp of 2016-05-20.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00918 (Start-259)
      • engineered mutation (64)
      • engineered mutation (66)
      • engineered mutation (68)
      • engineered mutation (90)
      • engineered mutation (129-130)
      • engineered mutation (133)
      • engineered mutation (202)
      • engineered mutation (204)
    Domains in SCOPe 2.06: d5g01a_
  • Heterogens: ZN, OE2, SO4, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5g01A (A:)
    mshhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslril
    nnghsfkvnfddsqdkavlkggpldgtyrltqfhfhwgsldgqgsehtvdkkkyaaelhl
    vhwntkygdaskasqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdp
    rgllpesldywtypgslttpplnetvtwivlkepisvsseqvlkfrklnfngegepeelm
    vdnwrpaqplknrqikasfk
    

    Sequence, based on observed residues (ATOM records): (download)
    >5g01A (A:)
    hhwgygkhngpehwhkdfpiakgerqspvdidthtakydpslkplsvsydqatslrilnn
    ghsfkvnfddsqdkavlkggpldgtyrltqfhfhwgsldgqgsehtvdkkkyaaelhlvh
    wntkygdaskasqqpdglavlgiflkvgsakpglqkvvdvldsiktkgksadftnfdprg
    llpesldywtypgslttpplnetvtwivlkepisvsseqvlkfrklnfngegepeelmvd
    nwrpaqplknrqikasfk