PDB entry 5f2e
View 5f2e on RCSB PDB site
Description: Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C
Class: hydrolase
Keywords: small GTPase domain, covalent inhibitor bound, switch II pocket, GDP bound, HYDROLASE
Deposited on
2015-12-01, released
2016-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-11-22, with a file datestamp of
2017-11-17.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: GTPase KRas
Species: Homo sapiens [TaxId:9606]
Gene: KRAS, KRAS2, RASK2
Database cross-references and differences (RAF-indexed):
- Uniprot P01116 (1-End)
- expression tag (0)
- engineered mutation (12)
- engineered mutation (51)
- engineered mutation (80)
- engineered mutation (118)
- engineered mutation (151)
- engineered mutation (153)
- engineered mutation (165-167)
Domains in SCOPe 2.08: d5f2ea1, d5f2ea2 - Heterogens: MG, GOL, 5UT, GLY, GDP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5f2eA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek
Sequence, based on observed residues (ATOM records): (download)
>5f2eA (A:)
gmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildta
gqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhk