PDB entry 5eya

View 5eya on RCSB PDB site
Description: TRIM25 RING domain in complex with Ubc13-Ub conjugate
Class: SIGNALING PROTEIN/Transferase
Keywords: Complex, E3 ligase, ubiquitination, SIGNALING PROTEIN-Transferase complex
Deposited on 2015-11-24, released 2016-08-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61088
      • engineered mutation (86)
    Domains in SCOPe 2.08: d5eyaa_
  • Chain 'B':
    Compound: Ubiquitin-conjugating enzyme E2 N
    Species: Homo sapiens [TaxId:9606]
    Gene: UBE2N, BLU
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61088
      • engineered mutation (86)
    Domains in SCOPe 2.08: d5eyab_
  • Chain 'C':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5eyac_
  • Chain 'D':
    Compound: Polyubiquitin-B
    Species: Homo sapiens [TaxId:9606]
    Gene: UBB
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5eyad_
  • Chain 'F':
    Compound: Tripartite motif-containing 25 variant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Tripartite motif-containing 25 variant
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q59GW5 (0-85)
      • conflict (2)
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eyaA (A:)
maglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpe
eypmaapkvrfmtkiyhpnvdklgrikldilkdkwspalqirtvllsiqallsapnpddp
landvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >5eyaA (A:)
glprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpeey
pmaapkvrfmtkiyhpnvdklgrikldilkdkwspalqirtvllsiqallsapnpddpla
ndvaeqwktneaqaietarawtrlyamnn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5eyaB (B:)
maglprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpe
eypmaapkvrfmtkiyhpnvdklgrikldilkdkwspalqirtvllsiqallsapnpddp
landvaeqwktneaqaietarawtrlyamnni

    Sequence, based on observed residues (ATOM records): (download) 
    >5eyaB (B:)
glprriiketqrllaepvpgikaepdesnaryfhvviagpqdspfeggtfklelflpeey
pmaapkvrfmtkiyhpnvdklgrikldilkdkwspalqirtvllsiqallsapnpddpla
ndvaeqwktneaqaietarawtrlyamnn

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5eyaC (C:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgg

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5eyaD (D:)
mqifvktltgktitlevepsdtienvkakiqdkegippdqqrlifagkqledgrtlsdyn
iqkestlhlvlrlrgg

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    No sequence available.