PDB entry 5ew3

View 5ew3 on RCSB PDB site
Description: Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993
Class: transferase
Keywords: kdr, kinase domain, ATP-binding site, VEGFR2 inhibitors, TRANSFERASE
Deposited on 2015-11-20, released 2015-12-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-01-27, with a file datestamp of 2016-01-22.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1, VEGFR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ew3a_
  • Chain 'B':
    Compound: Vascular endothelial growth factor receptor 2
    Species: Homo sapiens [TaxId:9606]
    Gene: KDR, FLK1, VEGFR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ew3b_
  • Heterogens: 5T2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ew3A (A:)
mdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtv
avkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnls
tylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnil
lseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvll
weifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfse
lvehlgnllqanaqqd

    Sequence, based on observed residues (ATOM records): (download) 
    >5ew3A (A:)
pydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtvavkmlkegathsehr
almselkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykv
kdfltlehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmap
etifdrvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpe
myqtmldcwhgepsqrptfselvehlgnllqana

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ew3B (B:)
mdpdelpldehcerlpydaskwefprdrlklgkplgrgafgqvieadafgidktatcrtv
avkmlkegathsehralmselkilihighhlnvvnllgactkpggplmvivefckfgnls
tylrskrnefvpykvapedlykdfltlehlicysfqvakgmeflasrkcihrdlaarnil
lseknvvkicdfglardiykdpdyvrkgdarlplkwmapetifdrvytiqsdvwsfgvll
weifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtmldcwhgepsqrptfse
lvehlgnllqanaqqd

    Sequence, based on observed residues (ATOM records): (download) 
    >5ew3B (B:)
lpydaskwefprdrlklgkplggqvieadafgidktatcrtvavkmlkegathsehralm
selkilihighhlnvvnllgactkpggplmvivefckfgnlstylrskrnefvpykdflt
lehlicysfqvakgmeflasrkcihrdlaarnillseknvvkicdfglplkwmapetifd
rvytiqsdvwsfgvllweifslgaspypgvkideefcrrlkegtrmrapdyttpemyqtm
ldcwhgepsqrptfselvehlgnllq