PDB entry 5elo

View 5elo on RCSB PDB site
Description: Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and cladosporin
Class: ligase/ligase inhibitor
Keywords: SSGCID, Lysine--tRNA ligase, Cryptosporidium parvum, ATP binding, aminoacylation, cladosporin, Structural Genomics, Seattle Structural Genomics Center for Infectious Disease, ligase-ligase inhibitor complex
Deposited on 2015-11-04, released 2016-11-16
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-11-16, with a file datestamp of 2016-11-11.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (19-20)
    Domains in SCOPe 2.06: d5eloa1, d5eloa2, d5eloa3
  • Chain 'B':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.06: d5elob1, d5elob2, d5elob3
  • Chain 'C':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.06: d5eloc1, d5eloc2, d5eloc3
  • Chain 'D':
    Compound: Lysine--tRNA ligase
    Species: Cryptosporidium parvum (strain Iowa II) [TaxId:353152]
    Gene: cgd4_2370
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q5CR27 (21-End)
      • expression tag (20)
    Domains in SCOPe 2.06: d5elod1, d5elod2, d5elod3
  • Heterogens: LYS, KRS, SO4, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eloA (A:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >5eloA (A:)
gshytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrv
tsirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgks
krgelslfsksvvllspcyhmlptaisglkdqevryrqryldlmlneesrkvfklrsrai
kyirnyfdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivgg
ldkvyeigknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslki
pyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheie
lphprtaaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgk
elcnaytelneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidr
limfladknnikevilfpamrn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5eloB (B:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >5eloB (B:)
shytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrvt
sirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgksk
rgelslfsksvvllspcyhmlptaisgldqevryrqryldlmlneesrkvfklrsraiky
irnyfdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivggld
kvyeigknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslkipy
hpdgpegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheielp
hprtaaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgkel
cnaytelneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidrli
mfladknnikevilfpamrn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5eloC (C:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >5eloC (C:)
shytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrvt
sirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgksk
rgelslfsksvvllspcyhmlptaidqevryrqryldlmlneesrkvfklrsraikyirn
yfdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivggldkvy
eigknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslkipyhpd
gpegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheielphpr
taaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgkelcna
ytelneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidrlimfl
adknnikevilfpamr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5eloD (D:)
mahhhhhhmgtleaqtqgpgshytdnrykmmecikdagrpfyphkfkismslpayalkyg
nvengyidkdttlslsgrvtsirssssklifydifceeqkvqiianimehdistgefsvs
hseirrgdvvgftgfpgkskrgelslfsksvvllspcyhmlptaisglkdqevryrqryl
dlmlneesrkvfklrsraikyirnyfdrlgflevetpmlnmiyggaaarpfityhnelet
qlymriapelylkqlivggldkvyeigknfrnegidlthnpeftamefymayadyydlmd
lteelisglvleihgslkipyhpdgpegkcieidfttpwkrfsfveeiesglgeklkrpl
dsqenidfmvemcekheielphprtaaklldklaghfvetkctnpsfiidhpqtmsplak
whrekpemterfelfvlgkelcnaytelneplqqrkffeqqadakasgdveacpidetfc
lalehglpptggwglgidrlimfladknnikevilfpamrnvkqnaqhsnqhsgn

    Sequence, based on observed residues (ATOM records): (download) 
    >5eloD (D:)
shytdnrykmmecikdagrpfyphkfkismslpayalkygnvengyidkdttlslsgrvt
sirssssklifydifceeqkvqiianimehdistgefsvshseirrgdvvgftgfpgksk
rgelslfsksvvllspcyhmlptaidqevryrqryldlmlneesrkvfklrsraikyirn
yfdrlgflevetpmlnmiyggaaarpfityhneletqlymriapelylkqlivggldkvy
eigknfrnegidlthnpeftamefymayadyydlmdlteelisglvleihgslkipyhpd
gpegkcieidfttpwkrfsfveeiesglgeklkrpldsqenidfmvemcekheielphpr
taaklldklaghfvetkctnpsfiidhpqtmsplakwhrekpemterfelfvlgkelcna
ytelneplqqrkffeqqadakasgdveacpidetfclalehglpptggwglgidrlimfl
adknnikevilfpamrn