PDB entry 5ek4

View 5ek4 on RCSB PDB site
Description: Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with NLG919 analogue
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: IDO1, inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2015-11-03, released 2015-12-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ek4a_
  • Chain 'B':
    Compound: Indoleamine 2,3-dioxygenase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IDO1, IDO, INDO
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ek4b_
  • Heterogens: HEM, 5PF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ek4A (A:)
mahamenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerve
klnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklel
ppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikv
iptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgn
pqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymp
pahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasq
qpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ek4A (A:)
skeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhlt
dhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcvl
anwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqmq
erdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvyeg
fwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsle
snpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflkt
vrstteksllk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ek4B (B:)
mahamenswtiskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerve
klnmlsidhltdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklel
ppilvyadcvlanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikv
iptvfkamqmqerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgn
pqlsdglvyegfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymp
pahrnflcslesnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasq
qpkenktsedpskleakgtggtdlmnflktvrstteksllkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ek4B (B:)
iskeyhideevgfalpnpqenlpdfyndwmfiakhlpdliesgqlrerveklnmlsidhl
tdhksqrlarlvlgcitmayvwgkghgdvrkvlprniavpycqlskklelppilvyadcv
lanwkkkdpnkpltyenmdvlfsfrdgdcskgfflvsllveiaaasaikviptvfkamqm
qerdtllkalleiasclekalqvfhqihdhvnpkaffsvlriylsgwkgnpqlsdglvye
gfwedpkefaggsagqssvfqcfdvllgiqqtaggghaaqflqdmrrymppahrnflcsl
esnpsvrefvlskgdaglreaydacvkalvslrsyhlqivtkyilipasqggtdlmnflk
tvrstteksllkeg