PDB entry 5eig

View 5eig on RCSB PDB site
Description: Engineered human cystathionine gamma lyase (E59T, E339V) to deplet cysteine
Class: lyase
Keywords: Cyst(e)inase, LYASE
Deposited on 2015-10-29, released 2016-11-09
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-11-09, with a file datestamp of 2016-11-04.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eiga_
  • Chain 'B':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigb_
  • Chain 'C':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigc_
  • Chain 'D':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigd_
  • Chain 'E':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eige_
  • Chain 'F':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigf_
  • Chain 'G':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigg_
  • Chain 'H':
    Compound: Cystathionine gamma-lyase
    Species: Homo sapiens [TaxId:9606]
    Gene: CTH
    Database cross-references and differences (RAF-indexed):
    • Uniprot P32929
      • engineered mutation (58)
      • engineered mutation (338)
    Domains in SCOPe 2.07: d5eigh_
  • Heterogens: SO4, CYS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eigA (A:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigA (A:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqggftysrsgnptrnclekav
aaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglkisfv
dcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfmspyf
qrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspidcylc
nrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctgmvt
fyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvlkndrdvlgisdtlir
lsvgledeedlledldqalkaahp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5eigB (B:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatkymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigB (B:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgahsgftysrsgnptrncle
kavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglki
sfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfms
pyfqrplalgadismysatkymnghsdvvmglvsvnceslhnrlrflqnslgavpspidc
ylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctg
mvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvkndrdvlgisdtl
irlsvgledeedlledldqalkaahp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5eigC (C:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigC (C:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgsgftysrsgnptrncl
ekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglk
isfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfm
spyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspid
cylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgct
gmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvlkndrdvlgisd
tlirlsvgledeedlledldqalkaahp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5eigD (D:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigD (D:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgasgftysrsgnptrnclek
avaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglkis
fvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfmsp
yfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspidcy
lcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctgm
vtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvlkndrdvlgisdtl
irlsvgledeedlledldqalkaahpp

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >5eigE (E:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigE (E:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqggftysrsgnptrnclekav
aaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglkisfv
dcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfmspyf
qrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspidcylc
nrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctgmvt
fyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvlkndrdvlgisdtlir
lsvgledeedlledldqalkaahpp

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >5eigF (F:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigF (F:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqghsgftysrsgnptrnclek
avaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglkis
fvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfmsp
yfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspidcy
lcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctgm
vtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthkndrdvlgisdtlirls
vgledeedlledldqalkaahp

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >5eigG (G:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigG (G:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqgftysrsgnptrncl
ekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglk
isfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfm
spyfqrplalgadismysatxymnghsdvvmglvsvnceslhnrlrflqnslgavpspid
cylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgct
gmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvlkndrdvlgisd
tlirlsvgledeedlledldqalkaahp

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >5eigH (H:)
mqekdassqgflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapgqhsgfty
srsgnptrnclekavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnry
frqvasefglkisfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhg
diilvvdntfmspyfqrplalgadismysatkymnghsdvvmglvsvnceslhnrlrflq
nslgavpspidcylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqh
elvkrqctgctgmvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvl
kndrdvlgisdtlirlsvgledeedlledldqalkaahppsgshs

    Sequence, based on observed residues (ATOM records): (download) 
    >5eigH (H:)
gflphfqhfatqaihvgqdpeqwtsravvppislsttfkqgapsgftysrsgnptrncle
kavaaldgakyclafasglaatvtithllkagdqiicmddvyggtnryfrqvasefglki
sfvdcskiklleaaitpetklvwietptnptqkvidiegcahivhkhgdiilvvdntfms
pyfqrplalgadismysatkymnghsdvvmglvsvnceslhnrlrflqnslgavpspidc
ylcnrglktlhvrmekhfkngmavaqflesnpwvekviypglpshpqhelvkrqctgctg
mvtfyikgtlqhaeiflknlklftlavslggfeslaelpaimthasvkndrdvlgisdtl
irlsvgledeedlledldqalkaahpp