PDB entry 5ea9

View 5ea9 on RCSB PDB site
Description: Crystal Structure of Trypanosoma cruzi Dihydroorotate Dehydrogenase in Complex with Neq0130
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: T. cruzi, Dihydroorotate Dehydrogenase, covalent inhibitor, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2015-10-15, released 2016-10-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-19, with a file datestamp of 2020-02-14.
Experiment type: XRAY
Resolution: 1.71 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (fumarate)
    Species: Trypanosoma cruzi strain CL Brener [TaxId:353153]
    Gene: PyrD,pyr4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ea9a_
  • Chain 'B':
    Compound: Dihydroorotate dehydrogenase (fumarate)
    Species: Trypanosoma cruzi strain CL Brener [TaxId:353153]
    Gene: PyrD,pyr4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5ea9b_
  • Heterogens: 5LM, GOL, FMN, EDO, NCO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5ea9A (A:)
smclklnlldhvfanpfmnaagvlcsteedlrcmtasssgalvsksctsaprdgnpepry
mafplgsinsmglpnlgfdfylkyasdlhdyskkplflsisglsveenvamvrrlapvaq
ekgvllelnlscpnvpgkpqvaydfeamrtylqqvslayglpfgvkmppyfdiahfdtaa
avlnefplvkfvtcvnsvgnglvidaesesvvikpkqgfgglggkyilptalanvnafyr
rcpdklvfgcggvysgedaflhilagasmvqvgtalqeegpgiftrledelleimarkgy
rtleefrgrvktie

    Sequence, based on observed residues (ATOM records): (download) 
    >5ea9A (A:)
mclklnlldhvfanpfmnaagvlcsteedlrcmtasssgalvsksctsaprdgnpeprym
afplgsinsmglpnlgfdfylkyasdlhdyskkplflsisglsveenvamvrrlapvaqe
kgvllelnlscpnvpgkpqvaydfeamrtylqqvslayglpfgvkmppyfdiahfdtaaa
vlnefplvkfvtcvnsvgnglvidaesesvvikpkqgfgglggkyilptalanvnafyrr
cpdklvfgcggvysgedaflhilagasmvqvgtalqeegpgiftrledelleimarkgyr
tleefrgrvktie

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ea9B (B:)
smclklnlldhvfanpfmnaagvlcsteedlrcmtasssgalvsksctsaprdgnpepry
mafplgsinsmglpnlgfdfylkyasdlhdyskkplflsisglsveenvamvrrlapvaq
ekgvllelnlscpnvpgkpqvaydfeamrtylqqvslayglpfgvkmppyfdiahfdtaa
avlnefplvkfvtcvnsvgnglvidaesesvvikpkqgfgglggkyilptalanvnafyr
rcpdklvfgcggvysgedaflhilagasmvqvgtalqeegpgiftrledelleimarkgy
rtleefrgrvktie

    Sequence, based on observed residues (ATOM records): (download) 
    >5ea9B (B:)
mclklnlldhvfanpfmnaagvlcsteedlrcmtasssgalvsksctsaprdgnpeprym
afplgsinsmglpnlgfdfylkyasdlhdyskkplflsisglsveenvamvrrlapvaqe
kgvllelnlscpnvpgkpqvaydfeamrtylqqvslayglpfgvkmppyfdiahfdtaaa
vlnefplvkfvtcvnsvgnglvidaesesvvikpkqgfgglggkyilptalanvnafyrr
cpdklvfgcggvysgedaflhilagasmvqvgtalqeegpgiftrledelleimarkgyr
tleefrgrvktie