PDB entry 5drt

View 5drt on RCSB PDB site
Description: Crystal structure of Dot1L in complex with inhibitor CPD2 [2-(2-(5-((2-chlorophenoxy)methyl)-1H-tetrazol-1-yl)acetyl)-N-(4-chlorophenyl)hydrazinecarboxamide]
Class: transferase
Keywords: Inhibitor, Complex, Methyltransferase, transferase
Deposited on 2015-09-16, released 2016-06-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-09-07, with a file datestamp of 2016-09-02.
Experiment type: XRAY
Resolution: 2.69 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5drta_
  • Chain 'B':
    Compound: Histone-lysine N-methyltransferase, H3 lysine-79 specific
    Species: Homo sapiens [TaxId:9606]
    Gene: DOT1L, KIAA1814, KMT4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5drtb_
  • Heterogens: 5EG, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5drtA (A:)
gpgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyv
lidydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsv
tdpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnc
khhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvif
vnnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspl
kgsvswtgkpvsyylhtidrtilenyfsslknpg

    Sequence, based on observed residues (ATOM records): (download) 
    >5drtA (A:)
lelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidyd
tksfesmqrlcdkynraidsihqlwkgntrpstgllrhilqqvynhsvtdpeklfspevy
getsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipakyae
tmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhqlker
fanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkgswtgkpvsyylhtid
rtilenyfsslknp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5drtB (B:)
gpgeklelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyv
lidydtksfesmqrlcdkynraidsihqlwkgttqpmklntrpstgllrhilqqvynhsv
tdpeklnnyepfspevygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnc
khhygvekadipakyaetmdrefrkwmkwygkkhaeytlergdflseewreriantsvif
vnnfafgpevdhqlkerfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelspl
kgsvswtgkpvsyylhtidrtilenyfsslknpg

    Sequence, based on observed residues (ATOM records): (download) 
    >5drtB (B:)
klelrlkspvgaepavypwplpvydkhhdaaheiietirwvceeipdlklamenyvlidy
dtksfesmqrlcdkynraidsihqlwkgtntrpstgllrhilqqvynhsvtdpeklfspe
vygetsfdlvaqmideikmtdddlfvdlgsgvgqvvlqvaaatnckhhygvekadipaky
aetmdrefrkwmkwygkkhaeytlergdflseewreriantsvifvnnfafgpevdhqlk
erfanmkeggrivsskpfaplnfrinsrnlsdigtimrvvelsplkswtgkpvsyylhti
drtilenyfsslkn