PDB entry 5dgj

View 5dgj on RCSB PDB site
Description: 1.0A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (20-mer) inhibitor
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: PROTEASE, NOROVIRUS, NORWALK VIRUS, ANTIVIRAL INHIBITORS, OXADIAZOLE INHIBITOR, CELL PERMEABLE, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2015-08-27, released 2016-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-12, with a file datestamp of 2020-08-07.
Experiment type: XRAY
Resolution: 1 Å
R-factor: N/A
AEROSPACI score: 0.89 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like protease
    Species: Norwalk virus [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.08: d5dgja1, d5dgja2
  • Heterogens: V64, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5dgjA (A:)
    mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
    eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
    vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
    gegetale
    

    Sequence, based on observed residues (ATOM records): (download)
    >5dgjA (A:)
    hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
    rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
    gmlltganakgmdlgdcgapyvhkrgndwvvcgvhaaatntvvcavqa