PDB entry 5dgj
View 5dgj on RCSB PDB site
Description: 1.0A resolution structure of Norovirus 3CL protease in complex an oxadiazole-based, cell permeable macrocyclic (20-mer) inhibitor
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: PROTEASE, NOROVIRUS, NORWALK VIRUS, ANTIVIRAL INHIBITORS, OXADIAZOLE INHIBITOR, CELL PERMEABLE, HYDROLASE-HYDROLASE inhibitor complex
Deposited on
2015-08-27, released
2016-02-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-08-12, with a file datestamp of
2020-08-07.
Experiment type: XRAY
Resolution: 1 Å
R-factor: N/A
AEROSPACI score: 0.89
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 3C-like protease
Species: Norwalk virus [TaxId:524364]
Gene: ORF1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5dgja1, d5dgja2 - Heterogens: V64, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5dgjA (A:)
mhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale
Sequence, based on observed residues (ATOM records): (download)
>5dgjA (A:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmlltganakgmdlgdcgapyvhkrgndwvvcgvhaaatntvvcavqa