PDB entry 5cu5

View 5cu5 on RCSB PDB site
Description: Crystal structure of ERAP2 without catalytic Zn(II) atom
Class: hydrolase
Keywords: hydrolase, aminopeptidase, endoplasmic reticulum, Thermolysin-like catalytic domain
Deposited on 2015-07-24, released 2015-09-23
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-09-23, with a file datestamp of 2015-09-18.
Experiment type: XRAY
Resolution: 3.02 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • expression tag (960)
    Domains in SCOPe 2.05: d5cu5a1, d5cu5a2, d5cu5a3, d5cu5a4
  • Chain 'B':
    Compound: Endoplasmic reticulum aminopeptidase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: ERAP2, LRAP
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q6P179 (Start-959)
      • expression tag (960)
    Domains in SCOPe 2.05: d5cu5b1, d5cu5b2, d5cu5b3, d5cu5b4
  • Heterogens: NAG, MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >5cu5A (A:)
    mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
    rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
    tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
    kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
    tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
    qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
    klwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyflnv
    cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
    ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
    wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
    hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
    glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
    nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
    sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
    ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
    ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
    rhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5cu5A (A:)
    pvatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhsk
    dleitnatlqseeymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgf
    egfykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnm
    pkvktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqt
    hyalqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpkts
    sasdklwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddy
    flnvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqk
    giiqylkkfsyrnaknddlwsslsnslgenaevkemmttwtlqkgipllvvkqdgcslrl
    qqerflqgvfqerylwhipltystsssnvihrhilksktdtldlpektswvkfnvdsngy
    yivhyeghgwdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhe
    tsspalleglsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrml
    rsallklacdlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqttagwnylle
    qyelsmssaeqnkilyalstskhqekllklielgmegkviktqnlaallhaiarrpkgqq
    lawdfvrenwthllkkfdlgsydirmiisgttahfsskdklqevklffesleaqgshldi
    fqtvletitknikwleknlptlrtwlmvntr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >5cu5B (B:)
    mvhssamvnshrkpmfnihrgfycltailpqicicsqfsvpssyhftedpgafpvatnge
    rfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskdleitna
    tlqseedsrymkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfegfy
    kstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpkvk
    tielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthyal
    qaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssasd
    klwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyflnv
    cfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgiiq
    ylkkfsyrnaknddlwsslsnsclesdftsggvchsdpkmtsnmlaflgenaevkemmtt
    wtlqkgipllvvkqdgcslrlqqerflqgvfqedpewralqerylwhipltystsssnvi
    hrhilksktdtldlpektswvkfnvdsngyyivhyeghgwdqlitqlnqnhtllrpkdrv
    glihdvfqlvgagrltldkaldmtyylqhetsspalleglsylesfyhmmdrrnisdise
    nlkryllqyfkpvidrqswsdkgsvwdrmlrsallklacdlnhapciqkaaelfsqwmes
    sgklniptdvlkivysvgaqttagwnylleqyelsmssaeqnkilyalstskhqekllkl
    ielgmegkviktqnlaallhaiarrpkgqqlawdfvrenwthllkkfdlgsydirmiisg
    ttahfsskdklqevklffesleaqgshldifqtvletitknikwleknlptlrtwlmvnt
    rhhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >5cu5B (B:)
    vatngerfpwqelrlpsvviplhydlfvhpnltsldfvasekievlvsnatqfiilhskd
    leitnatlqseedkpgkelkvlsypaheqiallvpekltphlkyyvamdfqaklgdgfeg
    fykstyrtlggetrilavtdfeptqarmafpcfdeplfkanfsikirresrhialsnmpk
    vktielegglledhfettvkmstylvayivcdfhslsgftssgvkvsiyaspdkrnqthy
    alqaslklldfyekyfdiyyplskldliaipdfapgamenwglityretsllfdpktssa
    sdklwvtrviahelahqwfgnlvtmewwndiwlkegfakymeliavnatypelqfddyfl
    nvcfevitkdslnssrpiskpaetptqiqemfdevsynkgacilnmlkdflgeekfqkgi
    iqylkkfsyrnaknddlwsslsnsaevkemmttwtlqkgipllvvkqdgcslrlqqerfl
    qgvrylwhipltystsssnvihrhilksktdtldlpektswvkfnvdsngyyivhyeghg
    wdqlitqlnqnhtllrpkdrvglihdvfqlvgagrltldkaldmtyylqhetsspalleg
    lsylesfyhmmdrrnisdisenlkryllqyfkpvidrqswsdkgsvwdrmlrsallklac
    dlnhapciqkaaelfsqwmessgklniptdvlkivysvgaqttagwnylleqyelsmssa
    eqnkilyalstskhqekllklielgmegkviktqnlaallhaiarrpkgqqlawdfvren
    wthllkkfdlgsydirmiisgttahfsskdklqevklffesleaqgshldifqtvletit
    knikwleknlptlrtwlmvntr