PDB entry 5c2h

View 5c2h on RCSB PDB site
Description: PDE10 complexed with 6-chloro-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-2-[3-(2-quinolyl)propoxy]pyrimidin-4-amine
Class: hydrolase/hydrolase inhibitor
Keywords: Phosphodiesterase, inhibitor, complex, hydrolase-hydrolase inhibitor complex
Deposited on 2015-06-15, released 2015-10-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-10-21, with a file datestamp of 2015-10-16.
Experiment type: XRAY
Resolution: 2.09 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5c2ha_
  • Chain 'B':
    Compound: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE10A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y233 (21-End)
      • expression tag (19-20)
    Domains in SCOPe 2.08: d5c2hb1, d5c2hb2
  • Heterogens: ZN, MG, 4PX, 4XU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5c2hA (A:)
mgsshhhhhhssglvprgshmsictseewqglmqftlpvrlckeielfhfdigpfenmwp
gifvymvhrscgtscfeleklcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtl
ftdlerkglliaclchdldhrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleg
hnifstlssseyeqvleiirkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrvig
lmmtacdlcsvtklwpvtkltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgql
gfynavaipcyttltqilpptepllkacrdnlsqwekvirgeetatwisspsvaqkaaas
ed

    Sequence, based on observed residues (ATOM records): (download) 
    >5c2hA (A:)
qftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfeleklcrfimsvkknyr
rvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdldhrgfsnsylqkfdh
plaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleiirkaiiatdlalyfg
nrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtkltandiyaefwaeg
demkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilpptepllkacrdnls
qwekvirg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5c2hB (B:)
mgsshhhhhhssglvprgshmsictseewqglmqftlpvrlckeielfhfdigpfenmwp
gifvymvhrscgtscfeleklcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtl
ftdlerkglliaclchdldhrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleg
hnifstlssseyeqvleiirkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrvig
lmmtacdlcsvtklwpvtkltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgql
gfynavaipcyttltqilpptepllkacrdnlsqwekvirgeetatwisspsvaqkaaas
ed

    Sequence, based on observed residues (ATOM records): (download) 
    >5c2hB (B:)
hmsictseewqglmqftlpvrlckeielfhfdigpfenmwpgifvymvhrscgtscfele
klcrfimsvkknyrrvpyhnwkhavtvahcmyailqnnhtlftdlerkglliaclchdld
hrgfsnsylqkfdhplaalyststmeqhhfsqtvsilqleghnifstlssseyeqvleii
rkaiiatdlalyfgnrkqleemyqtgslnlnnqshrdrviglmmtacdlcsvtklwpvtk
ltandiyaefwaegdemkklgiqpipmmdrdkkdevpqgqlgfynavaipcyttltqilp
ptepllkacrdnlsqwekvirg