PDB entry 5aix
View 5aix on RCSB PDB site
Description: Complex of human hematopoietic prostagandin D2 synthase (hH-PGDS) in complex with an active site inhibitor.
Class: transferase
Keywords: transferase, prostaglandin d2 synthase, pgds inhibitors, indole, focused screening, hit validation
Deposited on
2015-02-18, released
2015-06-03
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-06-10, with a file datestamp of
2015-06-05.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: hematopoietic prostaglandin d synthase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5aixa1, d5aixa2 - Chain 'B':
Compound: hematopoietic prostaglandin d synthase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5aixb1, d5aixb2 - Chain 'C':
Compound: hematopoietic prostaglandin d synthase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5aixc1, d5aixc2 - Chain 'D':
Compound: hematopoietic prostaglandin d synthase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d5aixd1, d5aixd2 - Heterogens: MG, GSH, KRX, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>5aixA (A:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl
Sequence, based on observed residues (ATOM records): (download)
>5aixA (A:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl
- Chain 'B':
Sequence, based on SEQRES records: (download)
>5aixB (B:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl
Sequence, based on observed residues (ATOM records): (download)
>5aixB (B:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl
- Chain 'C':
Sequence, based on SEQRES records: (download)
>5aixC (C:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl
Sequence, based on observed residues (ATOM records): (download)
>5aixC (C:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl
- Chain 'D':
Sequence, based on SEQRES records: (download)
>5aixD (D:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl
Sequence, based on observed residues (ATOM records): (download)
>5aixD (D:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltentdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl