PDB entry 5a4b

View 5a4b on RCSB PDB site
Description: Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.
Class: structural protein
Keywords: structural protein, calponin homology domains
Deposited on 2015-06-05, released 2016-06-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-06-22, with a file datestamp of 2016-06-17.
Experiment type: XRAY
Resolution: 2.01 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: human alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35609
      • engineered mutation (100)
    Domains in SCOPe 2.06: d5a4ba1, d5a4ba2
  • Chain 'B':
    Compound: human alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35609
      • engineered mutation (100)
    Domains in SCOPe 2.06: d5a4bb1, d5a4bb2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5a4bA (A:)
ymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlllev
isgerlpkpdrgkmrfhkianvnkaldyiaskgvklvsigteeivdgnvkmtlgmiwtii
lrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdli
dysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhafag
aeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a4bA (A:)
awekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmrf
hkianvnkaldyiaskgvklvsigteeivdgnvkmtlgmiwtiilrfaiqdisveetsak
eglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninl
ameiaekhldipkmldaedivntpkpderaimtyvscfyhafa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5a4bB (B:)
ymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlllev
isgerlpkpdrgkmrfhkianvnkaldyiaskgvklvsigteeivdgnvkmtlgmiwtii
lrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdli
dysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhafag
aeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a4bB (B:)
awekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmrf
hkianvnkaldyiaskgvklvsigteeivdgnvkmtlgmiwtiilrfaiqdisveetsak
eglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninl
ameiaekhldipkmldaedivntpkpderaimtyvscfyhafa