PDB entry 5a38

View 5a38 on RCSB PDB site
Description: Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.
Class: actin-binding protein
Keywords: actin-binding protein, human alpha-actinin-2, calponin homology domains
Deposited on 2015-05-27, released 2016-06-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2016-06-22, with a file datestamp of 2016-06-17.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5a38a1, d5a38a2
  • Chain 'B':
    Compound: alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d5a38b1, d5a38b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5a38A (A:)
gpymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlll
evisgerlpkpdrgkmrfhkianvnkaldyiaskgvklvsigaeeivdgnvkmtlgmiwt
iilrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpd
lidysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhaf
agaeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a38A (A:)
awekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmrf
hkianvnkaldyiaskgvklvsigaeeivdgnvkmtlgmiwtiilrfaiqdisveetsak
eglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninl
ameiaekhldipkmldaedivntpkpderaimtyvscfyhafa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5a38B (B:)
gpymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlll
evisgerlpkpdrgkmrfhkianvnkaldyiaskgvklvsigaeeivdgnvkmtlgmiwt
iilrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpd
lidysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhaf
agaeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a38B (B:)
awekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmrf
hkianvnkaldyiaskgvklvsigaeeivdgnvkmtlgmiwtiilrfaiqdisveetsak
eglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninl
ameiaekhldipkmldaedivntpkpderaimtyvscfyhafa