PDB entry 5a37

View 5a37 on RCSB PDB site
Description: Mutations in the Calponin homology domain of Alpha-Actinin-2 affect Actin binding and incorporation in muscle.
Class: actin-binding protein
Keywords: actin-binding protein, human alpha-actinin-2, calponin homology domains
Deposited on 2015-05-27, released 2016-06-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-08-24, with a file datestamp of 2016-08-18.
Experiment type: XRAY
Resolution: 1.88 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: human alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35609
      • engineered mutation (94)
    Domains in SCOPe 2.08: d5a37a1, d5a37a2
  • Chain 'B':
    Compound: human alpha-actinin-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35609
      • engineered mutation (94)
    Domains in SCOPe 2.08: d5a37b1, d5a37b2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5a37A (A:)
gpymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlll
evisgerlpkpdrgkmrfhkianvnkaldyiaskvvklvsigaeeivdgnvkmtlgmiwt
iilrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpd
lidysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhaf
agaeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a37A (A:)
pawekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmr
fhkianvnkaldyiaskvvigaeeivdgnvkmtlgmiwtiilrfaiqdisveetsakegl
llwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninlame
iaekhldipkmldaedivntpkpderaimtyvscfyhafa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5a37B (B:)
gpymiqeeewdrdllldpawekqqrktftawcnshlrkagtqienieedfrnglklmlll
evisgerlpkpdrgkmrfhkianvnkaldyiaskvvklvsigaeeivdgnvkmtlgmiwt
iilrfaiqdisveetsakeglllwcqrktapyrnvniqnfhtswkdglglcalihrhrpd
lidysklnkddpigninlameiaekhldipkmldaedivntpkpderaimtyvscfyhaf
agaeqaetaa

    Sequence, based on observed residues (ATOM records): (download) 
    >5a37B (B:)
awekqqrktftawcnshlrkagtqienieedfrnglklmlllevisgerlpkpdrgkmrf
hkianvnkaldyiaskvvigaeeivdgnvkmtlgmiwtiilrfaiqdisveetsakegll
lwcqrktapyrnvniqnfhtswkdglglcalihrhrpdlidysklnkddpigninlamei
aekhldipkmldaedivntpkpderaimtyvscfyhafa