PDB entry 4zxb

View 4zxb on RCSB PDB site
Description: structure of the human insulin receptor ectodomain, irdeltabeta construct, in complex with four fab molecules
Deposited on 2015-05-20, released 2016-02-24
The last revision was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3.3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fab 83-7 heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZXB (0-End)
    • Uniprot U5LP42 (Start-218)
  • Chain 'B':
    Compound: fab 83-7 light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZXB (0-112)
    • Uniprot P01837 (113-End)
  • Chain 'C':
    Compound: fab 83-14 heavy chain
    Species: Mus musculus [TaxId:10090]
    Gene: Igh-1a
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZXB (0-119)
    • Uniprot P01865 (120-End)
  • Chain 'D':
    Compound: fab 83-14 light chain
    Species: Mus musculus [TaxId:10090]
    Gene: Igkc, Igk-C
    Database cross-references and differences (RAF-indexed):
    • PDB 4ZXB (0-93)
    • Uniprot A2P1G9 (94-End)
  • Chain 'E':
    Compound: Insulin receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P06213 (0-End)
      • engineered mutation (143)
  • Heterogens: NAG

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >4zxbA (A:)
qvqlkesgpglvapsqslsitctvsgfpltaygvnwvrqppgkglewlgmiwgdgntdyn
salksrlsiskdnsksqvflkmnslqtddtaryycardpygskpmdywgqgtsvtvssak
ttppsvyplapgsaaqtnsmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdly
tlsssvtvpsstwpsetvtcnvahpasstkvdkkivprd

    Sequence, based on observed residues (ATOM records):
    >4zxbA (A:)
qvqlkesgpglvapsqslsitctvsgfpltaygvnwvrqppgkglewlgmiwgdgntdyn
salksrlsiskdnsksqvflkmnslqtddtaryycardpygskpmdywgqgtsvtvssak
ttppsvyplapgssmvtlgclvkgyfpepvtvtwnsgslssgvhtfpavlqsdlytlsss
vtvpsstwpsetvtcnvahpasstkvdkkivprd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >4zxbB (B:)
divmsqspsslvvsvgekvtmsckssqsllyssnqknflawyqqkpgqspklliywastr
esgvpdrftgsgsgtdftltissvkaedlavyycqqyfryrtfgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrnec

    Sequence, based on observed residues (ATOM records):
    >4zxbB (B:)
divmsqspsslvvsvgekvtmsckssqsllyssnqknflawyqqkpgqspklliywastr
esgvpdrftgsgsgtdftltissvkaedlavyycqqyfryrtfgggtkleikradaaptv
sifppsseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysm
sstltltkdeyerhnsytceathktstspivksfnrne

  • Chain 'C':
    Sequence, based on SEQRES records:
    >4zxbC (C:)
qvqlqqsgpelvkpgalvkisckasgytftnydihwvkqrpgqglewigwiypgdgstky
nekfkgkatltadkssstaymhlssltseksavyfcarewaywgqgtlvtvsaakttaps
vyplapvcgdttgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsss
vtvtsstwpsqsitcnvahpasstkvdkkieprgptikpc

    Sequence, based on observed residues (ATOM records):
    >4zxbC (C:)
qvqlqqsgpelvkpgalvkisckasgytftnydihwvkqrpgqglewigwiypgdgstky
nekfkgkatltadkssstaymhlseksavyfcarewaywgqgtlvtvsaakttapsvypl
apsvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytlsssvtvtcnvahpas
stkvdkk

  • Chain 'D':
    Sequence, based on SEQRES records:
    >4zxbD (D:)
diqmtqspsslsaslgervsltcrasqdiggnlywlqqgpdgtikrliyatssldsgvpk
rfsgsrsgsdysltisslesedfvdyyclqyssspwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstlt
ltkdeyerhnsytceathktstspivksfnrgec

    Sequence, based on observed residues (ATOM records):
    >4zxbD (D:)
diqmtqspsslsaslgervsltcrasqdiggnlywlqqgpdgtikrliyatssldsgvpk
rfsgsrsgsdysltisslesedfvdyyclqyssspwtfgggtkleikradaaptvsifpp
sseqltsggasvvcflnnfypkdinvkvlnswtdqdskdstysmsstlathktstspivk
sf

  • Chain 'E':
    Sequence, based on SEQRES records:
    >4zxbE (E:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednhivlnkddneecgdicpgtakgktncpatvingqfve
rcwthshcqkvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvet
cpppyyhfqdwrcvnfsfcqdlhhkcknsrrqgchqyvihnnkcipecpsgytmnssnll
ctpclgpcpkvchllegektidsvtsaqelrgctvingsliinirggnnlaaeleanlgl
ieeisgylkirrsyalvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnlt
itqgklffhynpklclseihkmeevsgtkgrqerndialktngdqascenellkfsyirt
sfdkillrwepywppdfrdllgfmlfykeapyqnvtefdgqdacgsnswtvvdidpplrs
ndpksqnhpgwlmrglkpwtqyaifvktlvtfsderrtygaksdiiyvqtdatnpsvpld
pisvsnsssqiilkwkppsdpngnithylvfwerqaedselfeldyclkglklpsrtwsp
pfesedsqkhnqseyedsageccscpktdsqilkeleessfrktfedylhnvvfvprpss
lgdvgnagnneehrpfekvvnkeslvisglrhftgyrielqacnqdtpeercsvaayvsa
rtmpeakaddivgpvtheifennvvhlmwqepkepnglivlyevsyrrygdeelhlcvsr
khfalergcrlrglspgnysvriratslagngswteptyfyvtdyldvpsniak

    Sequence, based on observed residues (ATOM records):
    >4zxbE (E:)
hlypgevcpgmdirnnltrlhelencsvieghlqillmfktrpedfrdlsfpklimitdy
lllfrvygleslkdlfpnltvirgsrlffnyalvifemvhlkelglynlmnitrgsvrie
knnelcylatidwsrildsvednhivlnkddneecgdicpgtncpatqfvercwthshcq
kvcptickshgctaeglcchseclgncsqpddptkcvacrnfyldgrcvetcpppyyhfq
dwrcvnfsfcqdlhhkckchqyvihnnkcipecpsgytmnssnllctpclgpcpkvchll
egektidsvtsaqelrgctvingsliinirggnnlaaeleanlglieeisgylkirrsya
lvslsffrklrlirgetleignysfyaldnqnlrqlwdwskhnltitqgklffhynpklc
lseihkmeevsgtkgrqerndialktngdqascenellkfsyirtsfdkillrwepywpp
dfrdllgfmlfykeapyqnvvvdidpplrsndpksqnhpgwlmrglkpwtqyaifvktlv
tfsderrtygaksdiiyvqtdatnpsvpldpisvsnsssqiilkwkppsdpngnithylv
fwerqaedselfeldyclkglklpsrkeleessfrktfedylheehrpfekvvnkeslvi
sglrhftgyrielqacnqdtpeercsvaayvsartmpeakaddivgpvtheifennvvhl
mwqepkepnglivlyevsyrrygdeelhlcvsrkhfalergcrlrglspgnysvrirats
lagngswteptyfyvtdyld