SCOPe 2.05: Structural Classification of Proteins

PDB entry 4zwl

View 4zwl on RCSB PDB site
Description: 2.60 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) H448F/Y450L double mutant from Staphylococcus aureus in complex with NAD+ and BME-free Cys289
Class: oxidoreductase
Keywords: BetB, structural genomics, NAD, NIAID, National Institute of Allergy and Infectious Diseases, CSGID, Rossmann fold, Center for Structural Genomics of Infectious Diseases, OXIDOREDUCTASE
Deposited on 2015-05-19, released 2015-05-27
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-05-27, with a file datestamp of 2015-05-22.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - expression tag (18-20)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwla_
Chain 'B':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - expression tag (18-20)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwlb_
Chain 'C':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - expression tag (18-20)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwlc_
Chain 'D':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - expression tag (19-20)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwld_
Chain 'E':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwle_
Chain 'F':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwlf_
Chain 'G':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwlg_
Chain 'H':
Compound: Betaine-aldehyde dehydrogenase
Species: Staphylococcus aureus (strain COL) [TaxId:93062]
Gene: betB, SACOL2628
Database cross-references and differences (RAF-indexed):
- Uniprot Q5HCU0 (21-516)
  - engineered mutation (468)
  - engineered mutation (470)
Domains in SCOPe 2.05: d4zwlh_
Heterogens: NAD, SO4, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>4zwlA (A:)
mgsshhhhhhssgrenlyfqgmellkhlsqrqyidgewvesankntrdiinpynqevift
vsegtkedaerailaarrafesgewsqetaetrgkkvraiadkikehrealarletldtg
ktleesyadmddihnvfmyfagladkdggemidspipdteskivkepvgvvtqitpwnyp
llqaswkiapalatgcslvmkpseitplttirvfelmeevgfpkgtinlilgagsevgdv
msghkevdlvsftggietgkhimknaannvtnialelggknpniifddadfelavdqaln
ggyfhagqvcsagsrilvqnsikdkfeqalidrvkkiklgngfdadtemgpvistehrnk
iesymdvakaegatiavggkrpdrddlkdglffeptvitncdtsmrivqeevfgpvvtve
gfeteqeaiqlandsiyglagavfskdigkaqrvanklklgtvwindffplfaqapwggy
kqsgigrelgkegleeylvskhiltntnpqlvnwfsk