PDB entry 4zsa

View 4zsa on RCSB PDB site
Description: Crystal structure of FGFR1 kinase domain in complex with 7n
Class: transferase/transferase inhibitor
Keywords: FGFR1 inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-05-13, released 2015-06-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-07-22, with a file datestamp of 2015-07-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362 (Start-307)
      • engineered mutation (30)
    Domains in SCOPe 2.07: d4zsaa_
  • Chain 'B':
    Compound: fibroblast growth factor receptor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P11362
      • engineered mutation (30)
    Domains in SCOPe 2.07: d4zsab_
  • Heterogens: 4UT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4zsaA (A:)
    agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
    sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
    ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
    kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
    gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
    valtsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4zsaA (A:)
    elpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdatek
    dlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppeeql
    sskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglardihhidyyk
    kttngrlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllke
    ghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivaltsnqe
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4zsaB (B:)
    agvseyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlk
    sdatekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarr
    ppgleysynpshnpeeqlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvm
    kiadfglardihhidyykkttngrlpvkwmapealfdriythqsdvwsfgvllweiftlg
    gspypgvpveelfkllkeghrmdkpsnctnelymmmrdcwhavpsqrptfkqlvedldri
    valtsnqe
    

    Sequence, based on observed residues (ATOM records): (download)
    >4zsaB (B:)
    eyelpedprwelprdrlvlgkplgegafgqvvlaeaigldkdkpnrvtkvavkmlksdat
    ekdlsdlisememmkmigkhkniinllgactqdgplyviveyaskgnlreylqarrppee
    qlsskdlvscayqvargmeylaskkcihrdlaarnvlvtednvmkiadfglidyykkttn
    grlpvkwmapealfdriythqsdvwsfgvllweiftlggspypgvpveelfkllkeghrm
    dkpsnctnelymmmrdcwhavpsqrptfkqlvedldrivalt