PDB entry 4zma

View 4zma on RCSB PDB site
Description: Crystal Structure of a FVIIa-Trypsin Chimera (ST) in Complex with Soluble Tissue Factor
Class: hydrolase
Keywords: fusion protein, trypsin-fold, protein-protein complex, hydrolase
Deposited on 2015-05-02, released 2015-12-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-12-21, with a file datestamp of 2016-12-16.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08709 (0-248)
      • engineered mutation (158-160)
      • engineered mutation (163-164)
    Domains in SCOPe 2.07: d4zmah_
  • Chain 'L':
    Compound: Coagulation factor VII
    Species: Homo sapiens [TaxId:9606]
    Gene: F7
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4zmal1, d4zmal2, d4zmal3
  • Chain 'T':
    Compound: tissue factor
    Species: Homo sapiens [TaxId:9606]
    Gene: F3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4zmat1, d4zmat2
  • Heterogens: CA, BGC, FUC, 0Z6, CAC, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4zmaH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdceasspgkiteymfcagysdgsk
dsckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrseprp
gvllrapfp

    Sequence, based on observed residues (ATOM records): (download) 
    >4zmaH (H:)
ivggkvcpkgecpwqvlllvngaqlcggtlintiwvvsaahcfdkiknwrnliavlgehd
lsehdgdeqsrrvaqviipstyvpgttnhdiallrlhqpvvltdhvvplclpertfsert
lafvrfslvsgwgqlldrgatalelmvlnvprlmtqdceasgkiteymfcagysdgskds
ckgdsggphathyrgtwyltgivswgqgcatvghfgvytrvsqyiewlqklmrseprpgv
llrapfp

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4zmaL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhtgtkrscrchegysl
ladgvsctptveypcgkipilekrnaskpqgr

    Sequence, based on observed residues (ATOM records): (download) 
    >4zmaL (L:)
anafleelrpgslereckeeqcsfeeareifkdaertklfwisysdgdqcasspcqnggs
ckdqlqsyicfclpafegrncethkddqlicvnenggceqycsdhkrscrchegysllad
gvsctptveypcgkipilekr

  • Chain 'T':
    Sequence, based on SEQRES records: (download) 
    >4zmaT (T:)
sgttntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdlt
deivkdvkqtylarvfsypagnvestgsageplyenspeftpyletnlgqptiqsfeqvg
tkvnvtvedertlvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvd
kgenycfsvqavipsrtvnrkstdspvecmgqekgefre

    Sequence, based on observed residues (ATOM records): (download) 
    >4zmaT (T:)
tntvaaynltwkstnfktilewepkpvnqvytvqistksgdwkskcfyttdtecdltdei
vkdvkqtylarvfsypageplyenspeftpyletnlgqptiqsfeqvgtkvnvtvedert
lvrrnntflslrdvfgkdliytlyywkssssgkktaktntneflidvdkgenycfsvqav
ipsrtvnrkstdspvecm