PDB entry 4zff
View 4zff on RCSB PDB site
Description: Dual-acting Fab 5A12 in complex with VEGF
Class: signaling protein/immune system
Keywords: Fab, DAF, angiogenesis, Tie receptor, SIGNALING PROTEIN-IMMUNE SYSTEM complex
Deposited on
2015-04-21, released
2015-07-01
The last revision prior to the SCOPe 2.08 freeze date was dated
2015-09-16, with a file datestamp of
2015-09-11.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Fragment antigen binding (Fab) 5A12 Heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffa_ - Chain 'B':
Compound: Fragment antigen binding (Fab) 5A12 Light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffb1, d4zffb2 - Chain 'C':
Compound: Vascular Endothelial Growth Factor A
Species: Homo sapiens [TaxId:9606]
Gene: VEGFA, VEGF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffc_ - Chain 'D':
Compound: Vascular Endothelial Growth Factor A
Species: Homo sapiens [TaxId:9606]
Gene: VEGFA, VEGF
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffd_ - Chain 'H':
Compound: Fragment antigen binding (Fab) 5A12 Heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffh_ - Chain 'L':
Compound: Fragment antigen binding (Fab) 5A12 Light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4zffl1, d4zffl2 - Heterogens: SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4zffA (A:)
evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht
Sequence, based on observed residues (ATOM records): (download)
>4zffA (A:)
evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
astkgpsvfplaptaalgclvkdyfpepvtvssgaltsgvhtfpavlqssglyslssvvt
vpssslgtqtyicnvnhkpsntkvdk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4zffB (B:)
diqmtqspsslsasvgdrvtitcrasqflssfgvawyqqkpgkapklliygasslysgvp
srfsgsgsgtdftltisslqpedfatyycqqgllspltfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4zffB (B:)
diqmtqspsslsasvgdrvtitcrasqflssfgvawyqqkpgkapklliygasslysgvp
srfsgsgsgtdftltisslqpedfatyycqqgllspltfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnsgnsqesvteqdskdstyslsstltls
kadyekhkvyacevthqglsspvtksfnrg
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4zffC (C:)
hhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvp
teesnitmqimrikphqgqhigemsflqhnkcecrpkkd
Sequence, based on observed residues (ATOM records): (download)
>4zffC (C:)
evvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvpte
esnitmqimrikphqgqhigemsflqhnkcecrpkk
- Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)
>4zffD (D:)
hhevvkfmdvyqrsychpietlvdifqeypdeieyifkpscvplmrcggccndeglecvp
teesnitmqimrikphqgqhigemsflqhnkcecrpkkd
- Chain 'H':
Sequence, based on SEQRES records: (download)
>4zffH (H:)
evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkvepkscdktht
Sequence, based on observed residues (ATOM records): (download)
>4zffH (H:)
evqlvesggglvqpggslrlscaasgftisdywihwvrqapgkglewvagitpaggytyy
adsvkgrftisadtskntaylqmnslraedtavyycarfvfflpyamdywgqgtlvtvss
astkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssv
vtvpssslgtqtyicnvnhkpsntkvdkkve
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4zffL (L:)
diqmtqspsslsasvgdrvtitcrasqflssfgvawyqqkpgkapklliygasslysgvp
srfsgsgsgtdftltisslqpedfatyycqqgllspltfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec
Sequence, based on observed residues (ATOM records): (download)
>4zffL (L:)
diqmtqspsslsasvgdrvtitcrasqflssfgvawyqqkpgkapklliygasslysgvp
srfsgsgsgtdftltisslqpedfatyycqqgllspltfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrg