PDB entry 4z78

View 4z78 on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on 2015-04-06, released 2015-06-24
The last revision prior to the SCOPe 2.05 freeze date was dated 2015-06-24, with a file datestamp of 2015-06-19.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: H-2 class I histocompatibility antigen, K-D alpha chain
  Species: Mus musculus [TaxId:10090]
  Gene: H2-K1, H2-K
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01902 (1-275)
    • initiating methionine (0)
    • conflict (114)
    • expression tag (276)
  Domains in SCOPe 2.05: d4z78a1, d4z78a2
• Chain 'B':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.05: d4z78b_
• Chain 'C':
  Compound: insulin
  Species: Homo sapiens [TaxId:9606]
  Gene: INS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01308 (0-9)
• Chain 'D':
  Compound: H-2 class I histocompatibility antigen, K-D alpha chain
  Species: Mus musculus [TaxId:10090]
  Gene: H2-K1, H2-K
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01902 (1-275)
    • initiating methionine (0)
    • conflict (114)
    • expression tag (276)
  Domains in SCOPe 2.05: d4z78d1, d4z78d2
• Chain 'E':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.05: d4z78e_
• Chain 'F':
  Compound: insulin
  Species: Homo sapiens [TaxId:9606]
  Gene: INS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01308 (0-9)
• Chain 'G':
  Compound: H-2 class I histocompatibility antigen, K-D alpha chain
  Species: Mus musculus [TaxId:10090]
  Gene: H2-K1, H2-K
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01902 (1-275)
    • initiating methionine (0)
    • conflict (114)
    • expression tag (276)
  Domains in SCOPe 2.05: d4z78g1, d4z78g2
• Chain 'H':
  Compound: Beta-2-microglobulin
  Species: Homo sapiens [TaxId:9606]
  Gene: B2M, CDABP0092, HDCMA22P
  Database cross-references and differences (RAF-indexed):
  • Uniprot P61769 (1-99)
    • initiating methionine (0)
  Domains in SCOPe 2.05: d4z78h_
• Chain 'I':
  Compound: insulin
  Species: Homo sapiens [TaxId:9606]
  Gene: INS
  Database cross-references and differences (RAF-indexed):
  • Uniprot P01308 (0-9)
• Heterogens: EDO, GOL, SO4, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78A (A:)
  mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
  weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
  grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
  lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
  tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78B (B:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78D (D:)
  mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
  weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
  grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
  lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
  tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
  

  
  
• Chain 'E':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78E (E:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'F':
  No sequence available.
  
  
• Chain 'G':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78G (G:)
  mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
  weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
  grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
  lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
  tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp
  

  
  
• Chain 'H':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4z78H (H:)
  miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
  wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
  

  
  
• Chain 'I':
  No sequence available.