PDB entry 4z77

View 4z77 on RCSB PDB site
Description: Weak TCR binding to an unstable insulin epitope drives type 1 diabetes
Class: immune system
Keywords: Immunoglobulin, H-2Kd, Type 1 Diabetes, Immune System
Deposited on 2015-04-06, released 2015-06-24
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-06-24, with a file datestamp of 2015-06-19.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.06: d4z77a1, d4z77a2, d4z77a3
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d4z77b1, d4z77b2
  • Chain 'C':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01308 (0-8)
      • engineered mutation (8)
  • Chain 'D':
    Compound: H-2 class I histocompatibility antigen, K-D alpha chain
    Species: Mus musculus [TaxId:10090]
    Gene: H2-K1, H2-K
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01902 (1-275)
      • initiating methionine (0)
      • conflict (114)
      • expression tag (276)
    Domains in SCOPe 2.06: d4z77d1, d4z77d2, d4z77d3
  • Chain 'E':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d4z77e1, d4z77e2
  • Chain 'F':
    Compound: insulin
    Species: Homo sapiens [TaxId:9606]
    Gene: INS
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01308 (0-8)
      • engineered mutation (8)
  • Heterogens: GOL, 15P, EDO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z77A (A:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z77B (B:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z77D (D:)
mgphslryfvtavsrpglgeprfiavgyvddtqfvrfdsdadnprfeprapwmeqegpey
weeqtqraksdeqwfrvslrtaqryynqskggshtfqrmfgcdvgsdwrllrgyhqfayd
grdyialnedlktwtaadtaalitrrkweqagdaeyyraylegecvewlrrylelgnetl
lrtdspkahvtyhprsqvdvtlrcwalgfypaditltwqlngedltqdmelvetrpagdg
tfqkwaavvvplgkeqnytchvhhkglpepltlrwkp

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4z77E (E:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'F':
    No sequence available.