PDB entry 4yv8

View 4yv8 on RCSB PDB site
Description: Crystal structure of cathepsin K bound to the covalent inhibitor lichostatinal
Class: hydrolase/inhibitor
Keywords: cathepsin K, lichostatinal, inhibitor, HYDROLASE-INHIBITOR complex
Deposited on 2015-03-19, released 2016-05-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cathepsin k
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSK, CTSO, CTSO2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4yv8a_
  • Chain 'B':
    Compound: Lichostatinal
    Species: actinomycete 095-35 [TaxId:701525]
    Database cross-references and differences (RAF-indexed):
    • PDB 4YV8 (0-4)
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4yv8A (A:)
apdsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsen
dgcgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegneka
lkravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwii
knswgenwgnkgyilmarnknnacgianlasfpkm

    Sequence, based on observed residues (ATOM records): (download) 
    >4yv8A (A:)
dsvdyrkkgyvtpvknqgqcgscwafssvgalegqlkkktgkllnlspqnlvdcvsendg
cgggymtnafqyvqknrgidsedaypyvgqeescmynptgkaakcrgyreipegnekalk
ravarvgpvsvaidasltsfqfyskgvyydescnsdnlnhavlavgygiqkgnkhwiikn
swgenwgnkgyilmarnknnacgianlasfpkm

  • Chain 'B':
    No sequence available.