PDB entry 4yuz

View 4yuz on RCSB PDB site
Description: Crystal structure of Trypanosoma cruzi spermidine synthase in complex with 5-[(4-methylbenzyl)oxy]quinazoline-2,4-diamine
Class: transferase
Keywords: methyltransferase, polyamine synthesis, TRANSFERASE
Deposited on 2015-03-19, released 2015-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Spermidine synthase, putative
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053510339.50
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4yuza_
  • Chain 'B':
    Compound: Spermidine synthase, putative
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053510339.50
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4yuzb_
  • Chain 'C':
    Compound: Spermidine synthase, putative
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053510339.50
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4yuzc_
  • Chain 'D':
    Compound: Spermidine synthase, putative
    Species: Trypanosoma cruzi (strain CL Brener) [TaxId:353153]
    Gene: Tc00.1047053510339.50
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4yuzd_
  • Heterogens: S4M, 4JV, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4yuzA (A:)
mahhhhhhmpgselisggwfreendqwpgqamslrvekvlydaptkfqhltifesdpkgp
wgtvmaldgciqvtdydefvyhevlghtslcshpkpervliigggdggvlrevlrhgtve
hcdlvdidgevmeqskqhfpqisrsladpratvrvgdglafvrqtpdntydvviidttdp
agpasklfgeafykdvlrilkpdgiccnqgesiwldleliekmsrfiretgfasvqyalm
hvptypcgsigtlvcskkagvdvtkplrpvedmpfakdlkyydsemhkasfalprfarhi
nnse

    Sequence, based on observed residues (ATOM records): (download) 
    >4yuzA (A:)
gwfreendqwpgqamslrvekvlydaptkfqhltifesdpkgpwgtvmaldgciqvtdyd
efvyhevlghtslcshpkpervliigggdggvlrevlrhgtvehcdlvdidgevmeqskq
hfpqisrsladpratvrvgdglafvrqtpdntydvviidttafykdvlrilkpdgiccnq
gesiwldleliekmsrfiretgfasvqyalmhvptypcgsigtlvcskkagvdvtkplrp
vedmpfakdlkyydsemhkasfalprfarhinn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4yuzB (B:)
mahhhhhhmpgselisggwfreendqwpgqamslrvekvlydaptkfqhltifesdpkgp
wgtvmaldgciqvtdydefvyhevlghtslcshpkpervliigggdggvlrevlrhgtve
hcdlvdidgevmeqskqhfpqisrsladpratvrvgdglafvrqtpdntydvviidttdp
agpasklfgeafykdvlrilkpdgiccnqgesiwldleliekmsrfiretgfasvqyalm
hvptypcgsigtlvcskkagvdvtkplrpvedmpfakdlkyydsemhkasfalprfarhi
nnse

    Sequence, based on observed residues (ATOM records): (download) 
    >4yuzB (B:)
elisggwfreepgqamslrvekvlydaptkfqhltifesdpkgpwgtvmaldgciqvtdy
defvyhevlghtslcshpkpervliigggdggvlrevlrhgtvehcdlvdidgevmeqsk
qhfpqisrsladpratvrvgdglafvrqtpdntydvviidttgeafykdvlrilkpdgic
cnqgesiwldleliekmsrfiretgfasvqyalmhvptypcgsigtlvcskkagvdvtkp
lrpvedmpfakdlkyydsemhkasfalprfarhinn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4yuzC (C:)
mahhhhhhmpgselisggwfreendqwpgqamslrvekvlydaptkfqhltifesdpkgp
wgtvmaldgciqvtdydefvyhevlghtslcshpkpervliigggdggvlrevlrhgtve
hcdlvdidgevmeqskqhfpqisrsladpratvrvgdglafvrqtpdntydvviidttdp
agpasklfgeafykdvlrilkpdgiccnqgesiwldleliekmsrfiretgfasvqyalm
hvptypcgsigtlvcskkagvdvtkplrpvedmpfakdlkyydsemhkasfalprfarhi
nnse

    Sequence, based on observed residues (ATOM records): (download) 
    >4yuzC (C:)
isggwfreendpgqamslrvekvlydaptkfqhltifesdpkgpwgtvmaldgciqvtdy
defvyhevlghtslcshpkpervliigggdggvlrevlrhgtvehcdlvdidgevmeqsk
qhfpqisrsladpratvrvgdglafvrqtpdntydvviidttafykdvlrilkpdgiccn
qgesiwldleliekmsrfiretgfasvqyalmhvptypcgsigtlvcskkagvdvtkplr
pvedmpfakdlkyydsemhkasfalprfarhinn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4yuzD (D:)
mahhhhhhmpgselisggwfreendqwpgqamslrvekvlydaptkfqhltifesdpkgp
wgtvmaldgciqvtdydefvyhevlghtslcshpkpervliigggdggvlrevlrhgtve
hcdlvdidgevmeqskqhfpqisrsladpratvrvgdglafvrqtpdntydvviidttdp
agpasklfgeafykdvlrilkpdgiccnqgesiwldleliekmsrfiretgfasvqyalm
hvptypcgsigtlvcskkagvdvtkplrpvedmpfakdlkyydsemhkasfalprfarhi
nnse

    Sequence, based on observed residues (ATOM records): (download) 
    >4yuzD (D:)
elisggwfreendpgqamslrvekvlydaptkfqhltifesdpkgpwgtvmaldgciqvt
dydefvyhevlghtslcshpkpervliigggdggvlrevlrhgtvehcdlvdidgevmeq
skqhfpqisrsladpratvrvgdglafvrqtpdntydvviidtgeafykdvlrilkpdgi
ccnqgesiwldleliekmsrfiretgfasvqyalmhvptypcgsigtlvcskkagvdvtk
plrpvedmpfakdlkyydsemhkasfalprfarhinn