PDB entry 4ye3

View 4ye3 on RCSB PDB site
Description: Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 with Inhibitor GRL-4410A
Class: hydrolase/hydrolase inhibitor
Keywords: HIV-1 Protease, Drug resistance, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2015-02-23, released 2015-06-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-12-05, with a file datestamp of 2018-11-30.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: N/A
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11678]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
    • engineered mutation (6)
    • engineered mutation (9)
    • engineered mutation (12)
    • engineered mutation (14)
    • engineered mutation (29)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (57)
    • engineered mutation (61-62)
    • engineered mutation (66)
    • engineered mutation (70)
    • engineered mutation (83)
    • engineered mutation (87-89)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d4ye3a_
• Chain 'B':
  Compound: Protease
  Species: Human immunodeficiency virus type 1 group M subtype B [TaxId:11678]
  Gene: gag-pol
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
    • engineered mutation (6)
    • engineered mutation (9)
    • engineered mutation (12)
    • engineered mutation (14)
    • engineered mutation (29)
    • engineered mutation (31-32)
    • engineered mutation (34-36)
    • engineered mutation (46)
    • engineered mutation (53)
    • engineered mutation (57)
    • engineered mutation (61-62)
    • engineered mutation (66)
    • engineered mutation (70)
    • engineered mutation (83)
    • engineered mutation (87-89)
    • engineered mutation (94)
  Domains in SCOPe 2.08: d4ye3b_
• Heterogens: Y1, CL, GOL, G04, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4ye3A (A:)
  pqitlwkrpfvtvkvggqlkealldtgadntifedinlpgrwkpkmvggiggflkvreyd
  qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4ye3B (B:)
  pqitlwkrpfvtvkvggqlkealldtgadntifedinlpgrwkpkmvggiggflkvreyd
  qvpieiaghkvigtvlvgptpvnvigrdtmtqigatlnf