PDB entry 4y5v

View 4y5v on RCSB PDB site
Description: Diabody 305 complex with EpoR
Class: protein binding/immune system
Keywords: diabody complex, receptor, protein binding-immune system complex
Deposited on 2015-02-12, released 2015-04-29
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-04-29, with a file datestamp of 2015-04-24.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: diabody 305 VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V
    Domains in SCOPe 2.06: d4y5va_
  • Chain 'B':
    Compound: Diabody 305 VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V (0-End)
    Domains in SCOPe 2.06: d4y5vb_
  • Chain 'C':
    Compound: erythropoietin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EPOR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered mutation (49)
      • engineered mutation (161)
    Domains in SCOPe 2.06: d4y5vc1, d4y5vc2
  • Chain 'D':
    Compound: diabody 305 VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V
    Domains in SCOPe 2.06: d4y5vd_
  • Chain 'E':
    Compound: Diabody 305 VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V (0-End)
    Domains in SCOPe 2.06: d4y5ve_
  • Chain 'F':
    Compound: erythropoietin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EPOR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered mutation (49)
      • engineered mutation (161)
    Domains in SCOPe 2.06: d4y5vf1, d4y5vf2
  • Chain 'G':
    Compound: diabody 305 VH domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V
    Domains in SCOPe 2.06: d4y5vg_
  • Chain 'H':
    Compound: Diabody 305 VL domain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4Y5V (0-End)
    Domains in SCOPe 2.06: d4y5vh_
  • Chain 'I':
    Compound: erythropoietin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EPOR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P19235
      • engineered mutation (49)
    Domains in SCOPe 2.06: d4y5vi1, d4y5vi2
  • Heterogens: GOL, PGE, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4y5vA (A:)
hsafagsevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikp
dgsekyyvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtl
vtvssggggs

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vA (A:)
sevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikpdgseky
yvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtlvtvssg
g

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4y5vB (B:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvlaaaggg

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vB (B:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4y5vC (C:)
fagsadpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqlede
pwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlld
apvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecv
lsnlrgrtrytfavrarmaepsfggfwsawsepvslltpsdldkekaaa

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vC (C:)
pkfeskaallaargpeellcfterledlvcfweeapgqysfsyqledepwklcrlhqapt
agavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvglvarlades
ghvvlrwlpppetpmtshiryevdvsagqgsvqrveilegrtecvlsnlrgrtrytfavr
armaepsfggfwsawsepvslltpsd

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4y5vD (D:)
hsafagsevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikp
dgsekyyvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtl
vtvssggggs

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vD (D:)
sevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikpdgseky
yvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtlvtvssg
gg

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4y5vE (E:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvlaaaggg

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vE (E:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4y5vF (F:)
fagsadpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqlede
pwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlld
apvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecv
lsnlrgrtrytfavrarmaepsfggfwsawsepvslltpsdldkekaaa

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vF (F:)
pkfeskaallaargpeellcfterledlvcfweeaapgqysfsyqledepwklcrlhqap
targavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvglvarlae
sghvvlrwlpppetpmtshiryevdvsagqsvqrveilegrtecvlsnlrgrtrytfavr
armaepsfggfwsawsepvslltpsd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4y5vG (G:)
hsafagsevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikp
dgsekyyvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtl
vtvssggggs

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vG (G:)
sevqlvesggglvqpggslrlscaasgftfssywmswvrqapgkglewvanikpdgseky
yvdsvkgrftisrdnaknsvylqmnslraedtavyycarvsrggsysdwgqgtlvtvss

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4y5vH (H:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvlaaaggg

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vH (H:)
sqsaltqpasvsgspgqsitisctgtssdvggyiyvswyqqhpgkapklmiydvsrrpsg
isdrfsgsksgntasltisglqaedeadyycnsyttlstwlfgggtkvtvla

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4y5vI (I:)
fagsadpkfeskaallaargpeellcfterledlvcfweeaasagvgpgqysfsyqlede
pwklcrlhqaptargavrfwcslptadtssfvplelrvtaasgapryhrvihinevvlld
apvglvarladesghvvlrwlpppetpmtshiryevdvsagqgagsvqrveilegrtecv
lsnlrgrtrytfavrarmaepsfggfwsawsepvslltpsdldkekaaa

    Sequence, based on observed residues (ATOM records): (download) 
    >4y5vI (I:)
kfeskaallaargpeellcfterledlvcfweeaapgqysfsyqledepwklcrlhqapt
avrfwcslptadtssfvplelrvtaasgapryhrvihinevvlldapvglvarlsghvvl
rwlpppetpmtshiryevdvsavqrveilegrtecvlsngrtrytfavrarmaepsfggf
wsawsepvsll