PDB entry 4xzh

View 4xzh on RCSB PDB site
Description: Crystal structure of human Aldose Reductase complexed with NADP+ and JF0048
Class: oxidoreductase
Keywords: TIM barrel, Aldose reductase, oxidoreductase, diabetes, Halogenated compound, Cytosolic
Deposited on 2015-02-04, released 2015-11-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-01-27, with a file datestamp of 2016-01-22.
Experiment type: XRAY
Resolution: 1 Å
R-factor: N/A
AEROSPACI score: 0.82 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1B1, ALDR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (0-315)
      • conflict (4)
    Domains in SCOPe 2.08: d4xzha_
  • Chain 'B':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1B1, ALDR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (0-315)
      • conflict (4)
    Domains in SCOPe 2.08: d4xzhb_
  • Heterogens: NAP, 48I, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4xzhA (A:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4xzhB (B:)
    masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
    eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
    effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
    avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
    hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
    llsctshkdypfheef