PDB entry 4xwa

View 4xwa on RCSB PDB site
Description: TMK from S.aureus in complex with the Piperidinyl Thymine class inhibitor with a C5 ethyl-amine
Class: transferase
Keywords: TMK, kinase, antibacterial, piperidine, thymidine, TRANSFERASE
Deposited on 2015-01-28, released 2015-02-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-02-11, with a file datestamp of 2015-02-06.
Experiment type: XRAY
Resolution: 1.89 Å
R-factor: 0.194
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thymidylate kinase
    Species: Staphylococcus aureus (strain Mu3 / ATCC 700698) [TaxId:418127]
    Gene: tmk, SAHV_0479
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4xwaa_
  • Chain 'B':
    Compound: thymidylate kinase
    Species: Staphylococcus aureus (strain Mu3 / ATCC 700698) [TaxId:418127]
    Gene: tmk, SAHV_0479
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4xwab_
  • Heterogens: 43N, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4xwaA (A:)
    msafitfegpegsgkttvinevyhrlvkdydvimtrepggvptgeeirkivlegndmdir
    teamlfaasrrehlvlkvipalkegkvvlcdryidsslayqgyargigveevralnefai
    nglypdltiylnvsaevgreriiknsrdqnrldqedlkfhekviegyqeiihnesqrfks
    vnadqplenvvedtyqtiikyleki
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xwaA (A:)
    safitfegpegsgkttvinevyhrlvkdydvimtrepggvptgeeirkivlegndmdirt
    eamlfaasrrehlvlkvipalkegkvvlcdryidsslayqgyargigveevralnefain
    glypdltiylnvsaevgreriiknsrldqedlkfhekviegyqeiihnesqrfksvnadq
    plenvvedtyqtiikyleki
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4xwaB (B:)
    msafitfegpegsgkttvinevyhrlvkdydvimtrepggvptgeeirkivlegndmdir
    teamlfaasrrehlvlkvipalkegkvvlcdryidsslayqgyargigveevralnefai
    nglypdltiylnvsaevgreriiknsrdqnrldqedlkfhekviegyqeiihnesqrfks
    vnadqplenvvedtyqtiikyleki
    

    Sequence, based on observed residues (ATOM records): (download)
    >4xwaB (B:)
    safitfegpegsgkttvinevyhrlvkdydvimtrepggvptgeeirkivlegndmdirt
    eamlfaasrrehlvlkvipalkegkvvlcdryidsslayqgyargigveevralnefain
    glypdltiylnvsaevgreriiknldqedlkfhekviegyqeiihnesqrfksvnadqpl
    envvedtyqtiikyleki