PDB entry 4xw2

View 4xw2 on RCSB PDB site
Description: Structural basis for simvastatin competitive antagonism of complement receptor 3
Class: immune system
Keywords: immune system, Complement receptor 3, Rossmann fold, integrin, statin, protein-inhibitor complex, Mac-1, I domain, vWA
Deposited on 2015-01-28, released 2016-01-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-17, with a file datestamp of 2018-01-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Integrin alpha-M
    Species: Homo sapiens [TaxId:9606]
    Gene: ITGAM, CD11B, CR3A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xw2a_
  • Heterogens: MG, SIM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xw2A (A:)
gamgspqedsdiaflidgsgsiiphdfrrmkefvstvmeqlkksktlfslmqyseefrih
ftfkefqnnpnprslvkpitqllgrthtatgirkvvrelfnitngarknafkilvvitdg
ekfgdplgyedvipeadregviryvigvgdafrseksrqelntiaskpprdhvfqvnnfe
alktiqnqlrekgfaieg

    Sequence, based on observed residues (ATOM records): (download) 
    >4xw2A (A:)
dsdiaflidgsgsiiphdfrrmkefvstvmeqlkksktlfslmqyseefrihftfkefqn
npnprslvkpitqllgrthtatgirkvvrelfnitngarknafkilvvitdgekfgdplg
yedvipeadregviryvigvgdafrseksrqelntiaskpprdhvfqvnnfealktiqnq
lrek