PDB entry 4xsc

View 4xsc on RCSB PDB site
Description: Complex structure of thymidylate synthase from varicella zoster virus with a phosphorylated BVDU
Class: transferase
Keywords: VZV, thymidylate synthase, herpesvirus, transferase
Deposited on 2015-01-22, released 2015-12-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-12-16, with a file datestamp of 2015-12-11.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Varicella-zoster virus (strain Oka vaccine) [TaxId:341980]
    Gene: ORF13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xsca_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Varicella-zoster virus (strain Oka vaccine) [TaxId:341980]
    Gene: ORF13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xscb_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Varicella-zoster virus (strain Oka vaccine) [TaxId:341980]
    Gene: ORF13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xscc_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Varicella-zoster virus (strain Oka vaccine) [TaxId:341980]
    Gene: ORF13
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xscd_
  • Heterogens: BVP, 1PE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xscA (A:)
mhhhhhhssgvdlgtenlyfqsmtkvpgftltgelqylkqvddilrygvrkrdrtgigtl
slfgmqarynlrnefpllttkrvfwravveellwfirgstdskelaakdihiwdiygssk
flnrngfhkrhtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlqtvidtiktnpesrr
miisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglgvpfniagyalltyi
vahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkiirnvtdindfkwddf
qldgynphppl

    Sequence, based on observed residues (ATOM records): (download) 
    >4xscA (A:)
tltgelqylkqvddilrygvrkrdrtgigtlslfgmqarynlrnefpllttkrvfwravv
eellwfirgstdskelaakdihiwdtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlq
tvidtiktnpesrrmiisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglg
vpfniagyalltyivahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkii
rnvtdindfkwddfqldgynphp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xscB (B:)
mhhhhhhssgvdlgtenlyfqsmtkvpgftltgelqylkqvddilrygvrkrdrtgigtl
slfgmqarynlrnefpllttkrvfwravveellwfirgstdskelaakdihiwdiygssk
flnrngfhkrhtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlqtvidtiktnpesrr
miisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglgvpfniagyalltyi
vahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkiirnvtdindfkwddf
qldgynphppl

    Sequence, based on observed residues (ATOM records): (download) 
    >4xscB (B:)
gftltgelqylkqvddilrygvrkrdrtgigtlslfgmqarynlrnefpllttkrvfwra
vveellwfirgstdskelaakdihiwdiygsskflnrngfhkrhtgdlgpiygfqwrhfg
aeykdcqsnylqqgidqlqtvidtiktnpesrrmiisswnpkdiplmvlppchtlcqfyv
angelscqvyqrsgdmglgvpfniagyalltyivahvtglktgdlihtmgdahiylnhid
alkvqlarspkpfpclkiirnvtdindfkwddfqldgynphppl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4xscC (C:)
mhhhhhhssgvdlgtenlyfqsmtkvpgftltgelqylkqvddilrygvrkrdrtgigtl
slfgmqarynlrnefpllttkrvfwravveellwfirgstdskelaakdihiwdiygssk
flnrngfhkrhtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlqtvidtiktnpesrr
miisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglgvpfniagyalltyi
vahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkiirnvtdindfkwddf
qldgynphppl

    Sequence, based on observed residues (ATOM records): (download) 
    >4xscC (C:)
ltgelqylkqvddilrygvrkrdrtgigtlslfgmqarynlrnefpllttkrvfwravve
ellwfirgstdskelaakdihiwdtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlqt
vidtiktnpesrrmiisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglgv
pfniagyalltyivahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkiir
nvtdindfkwddfqldgynphppl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4xscD (D:)
mhhhhhhssgvdlgtenlyfqsmtkvpgftltgelqylkqvddilrygvrkrdrtgigtl
slfgmqarynlrnefpllttkrvfwravveellwfirgstdskelaakdihiwdiygssk
flnrngfhkrhtgdlgpiygfqwrhfgaeykdcqsnylqqgidqlqtvidtiktnpesrr
miisswnpkdiplmvlppchtlcqfyvangelscqvyqrsgdmglgvpfniagyalltyi
vahvtglktgdlihtmgdahiylnhidalkvqlarspkpfpclkiirnvtdindfkwddf
qldgynphppl

    Sequence, based on observed residues (ATOM records): (download) 
    >4xscD (D:)
tltgelqylkqvddilrygvrkrdrtgigtlslfgmqarynlrnefpllttkrvfwravv
eellwfirgstdskelaakdihiwdiygsskflnrngfhkrhtgdlgpiygfqwrhfgae
ykdcqsnylqqgidqlqtvidtiktnpesrrmiisswnpkdiplmvlppchtlcqfyvan
gelscqvyqrsgdmglgvpfniagyalltyivahvtglktgdlihtmgdahiylnhidal
kvqlarspkpfpclkiirnvtdindfkwddfqldgynphppl