PDB entry 4xpb
View 4xpb on RCSB PDB site
Description: X-ray structure of Drosophila dopamine transporter with subsiteB mutations (D121G/S426M) bound to cocaine
Class: tranport protein/inhibitor
Keywords: integral membrane protein, all-alpha helical antidepressant complex, tranport protein-inhibitor complex
Deposited on
2015-01-16, released
2015-05-13
The last revision prior to the SCOPe 2.06 freeze date was dated
2015-06-03, with a file datestamp of
2015-05-29.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.13
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Transporter
Species: Drosophila melanogaster [TaxId:7227]
Gene: DAT, CG8380, Dmel_CG8380
Database cross-references and differences (RAF-indexed):
- Uniprot Q7K4Y6
- engineered mutation (54)
- engineered mutation (101)
- engineered mutation (352)
- engineered mutation (363)
- Chain 'H':
Compound: antibody fragment light chain-protein, 9d5-light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: antibody fragment heavy chain-protein, 9d5-heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4xpbl1, d4xpbl2 - Heterogens: NA, COC, N9S, CLR, CL, HOH