PDB entry 4xp4
View 4xp4 on RCSB PDB site
Description: X-ray structure of Drosophila dopamine transporter in complex with cocaine
Class: transport protein/inhibitor
Keywords: integral membrane protein, all-alpha helical antidepressant complex, membrane protein-tranport protein complex, transport protein-inhibitor complex
Deposited on
2015-01-16, released
2015-05-06
The last revision prior to the SCOPe 2.06 freeze date was dated
2015-06-03, with a file datestamp of
2015-05-29.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Dopamine transporter
Species: Drosophila melanogaster [TaxId:7227]
Gene: DAT, CG8380, Dmel_CG8380
Database cross-references and differences (RAF-indexed):
- Uniprot Q7K4Y6
- engineered mutation (54)
- engineered mutation (354)
- Chain 'H':
Compound: antibody fragment heavy chain-protein, 9d5-light chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
- Chain 'L':
Compound: antibody fragment heavy chain-protein, 9d5-heavy chain
Species: Mus musculus [TaxId:10090]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4xp4l1, d4xp4l2 - Heterogens: Y01, P4G, MAL, CLR, COC, NA, CL, HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'H':
No sequence available.
- Chain 'L':
Sequence, based on SEQRES records: (download)
>4xp4L (L:)
mdfqvqifsfllisasvamsrgenvltqspaimstspgekvtmtcrasssvgssylhwyq
qksgaspklwiystsnlasgvparfsgsgsgtsysltissveaedaatyycqqfsgyplt
fgsgtklemkradaaptvsifppsseqltsggasvvcflnnfypkdinvkwkidgserqn
gvlnswtdqdskdstysmsstltltkdeyerhnsytceathktstspivksfnrnec
Sequence, based on observed residues (ATOM records): (download)
>4xp4L (L:)
envltqspaimstspgekvtmtcrasssvgssylhwyqqksgaspklwiystsnlasgvp
arfsgsgsgtsysltissveaedaatyycqqfsgypltfgsgtklemkradaaptvsifp
psseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstl
tltkdeyerhnsytceathktstspivksfnrne