PDB entry 4xnx

View 4xnx on RCSB PDB site
Description: X-ray structure of Drosophila dopamine transporter in complex with reboxetine
Class: transport protein/inhibitor
Keywords: integral membrane protein, all-alpha helical antidepressant complex, transport protein-inhibitor complex
Deposited on 2015-01-16, released 2015-05-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transporter
    Species: Drosophila melanogaster [TaxId:7227]
    Gene: DAT, Dmel_CG8380
    Database cross-references and differences (RAF-indexed):
    • Uniprot A0A0B4KEX2 (0-535)
      • engineered mutation (49)
      • engineered mutation (349)
  • Chain 'H':
    Compound: Antibody fragment Heavy chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XNX
    Domains in SCOPe 2.08: d4xnxh_
  • Chain 'L':
    Compound: Antibody fragment Light chain
    Species: Mus musculus [TaxId:10090]
    Database cross-references and differences (RAF-indexed):
    • PDB 4XNX (0-213)
    Domains in SCOPe 2.08: d4xnxl1, d4xnxl2
  • Heterogens: CLR, NA, CL, 41X, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4xnxH (H:)
mnfglrlvflvlilkgvqcevqlvesggglvkpggslklscaasgftfssyamswvrqsp
ekrlewvaeissggryiyysdtvtgrftisrdnarnilhlemsslrsedtamyycargev
rqrgfdywgqgttltvssakttapsvyplapvcgdttgssvtlgclvkgyfpepvtltwn
sgslssgvhtfpavlqsdlytlsssvtvtsstwpsqsitcnvahpasstkvdkkieprgp

    Sequence, based on observed residues (ATOM records): (download) 
    >4xnxH (H:)
evqlvesggglvkpggslklscaasgftfssyamswvrqspekrlewvaeissggryiyy
sdtvtgrftisrdnarnilhlemsslrsedtamyycargevrqrgfdywgqgttltvssa
kttapsvyplapvctgssvtlgclvkgyfpepvtltwnsgslssgvhtfpavlqsdlytl
sssvtvtsstwpsqsitcnvahpasstkvdkkiepr

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4xnxL (L:)
envltqspaimstspgekvtmtcrasssvgssylhwyqqksgaspklwiystsnlasgvp
arfsgsgsgtsysltissveaedaatyycqqfsgypltfgsgtklemkradaaptvsifp
psseqltsggasvvcflnnfypkdinvkwkidgserqngvlnswtdqdskdstysmsstl
tltkdeyerhnsytceathktstspivksfnrne