PDB entry 4xli

View 4xli on RCSB PDB site
Description: Crystal structure of Abl2/Arg kinase in complex with dasatinib
Class: transferase/transferase inhibitor
Keywords: Transferase, inhibitor, kinase, transferase-transferase inhibitor complex
Deposited on 2015-01-13, released 2015-04-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.21 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-specific protein-tyrosine kinase
    Species: Mus musculus [TaxId:10090]
    Gene: ABL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xlia_
  • Chain 'B':
    Compound: Non-specific protein-tyrosine kinase
    Species: Mus musculus [TaxId:10090]
    Gene: ABL2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xlib_
  • Heterogens: 1N1, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xliA (A:)
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissame
ylekknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapesla
yntfsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelm
racwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >4xliA (A:)
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkeveeflkeaavmkeikhp
nlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissameylek
knfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslayntf
siksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmracw
kwspadrpsfaethqafetmfhds

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xliB (B:)
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissame
ylekknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapesla
yntfsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelm
racwkwspadrpsfaethqafetmfhds

    Sequence, based on observed residues (ATOM records): (download) 
    >4xliB (B:)
dkwemertditmkhklggevyvgvwkkysltvavktlkedtmeveeflkeaavmkeikhp
nlvqllgvctleppfyivteympygnlldylrecsreevtavvllymatqissameylek
knfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapeslayntf
siksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelmracw
kwspadrpsfaethqafetmfhds