PDB entry 4xj0

View 4xj0 on RCSB PDB site
Description: Crystal structure of ERK2 in complex with an inhibitor 14K
Class: transferase/transferase inhibitor
Keywords: protein Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-01-08, released 2015-09-16
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-09-16, with a file datestamp of 2015-09-11.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xj0a_
  • Chain 'B':
    Compound: Mitogen-activated protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK1, ERK2, PRKM1, PRKM2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4xj0b_
  • Heterogens: 41B, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xj0A (A:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4xj0A (A:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpy
leqyydpsdepiaeapfkfelddlpkeklkelifeetarfqpgyrs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xj0B (B:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
lnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahp
yleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqpgyrs

    Sequence, based on observed residues (ATOM records): (download) 
    >4xj0B (B:)
emvrgqvfdvgprytnlsyigegaygmvcsaydnvnkvrvaikkispfehqtycqrtlre
ikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyfly
qilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyvatr
wyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqed
karnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyyd
psdepiaeapfkfdmelddlpkeklkelifeetarfqpg